Neuronal cyclin-dependent kinase 5 [cdk5] and its specific inhibitor [CIP]: its physiological and pathological role in the nervous system

• Autorzy: Zheng Y , Kesavapany S. , Pant H.C.
• Języki publikacji: EN

Słowa kluczowe

EN

multifunctional kinase; cyclin-dependent kinase 5; neuronal cell; nervous system; signal transduction; neuronal behaviour; growth; inhibitor; differentiation; survival

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2003
• Tom: 08
• Numer: 2A
• Opis fizyczny: p.558-560

Twórcy

autor

Zheng Y

autor

Kesavapany S.

autor

Pant H.C.

Bibliografia

• 1. Ohshima, T., Ward, J.M., Huh, C.G., Longenecker, G., Veeranna, Pant, H.C., Brady, R.O., Martin, L.J. and Kulkarni, A.B. Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc. Natl. Acad. Sci. USA 93 (1996) 11173-11178.
• 2. Tanaka, T., Veeranna, Ohshima, T., Rajan, P., Amin, N.D., Cho, A., Sreenath, T., Pant, H.C., Brady, R.O. and Kulkarni, A.B. Neuronal cyclin-dependent kinase 5 activity is critical for survival. J. Neurosci. 21 (2001) 550-558.
• 3. Tsai, L.H., Delalle, I., Caviness, V.S., Jr., Chae, T. and Harlow, E. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature 371 (1994) 419-423.
• 4. Lew, J„ Huang, Q.Q., Qi, Z., Winkfein, R.J., Aebersold, R., Hunt, T. and Wang, J.H. A brain-specific activator of cyclin-dependent kinase 5. Nature 371 (1994) 423-426.
• 5. Ko, J., Humbert, S., Bronson, R.T., Takahashi, S., Kulkarni, A.B., Li, E. and Tsai, L.H. p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J. Neurosci. 24 (2001) 6758-6771.
• 6. Sharma, P., Veeranna, Sharma, M., Amin, N.D., Sihag, R.K., Grant, P., Ahn, N., Kulkarni, A.B. and Pant, H.C. Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway. J. Biol. Chem. 277 (2002) 528-534.
• 7. Li, B.S., Zhang, L., Takahashi, S., Ma, W., Jaffe, H., Kulkarni, A.B. and Pant, H.C. Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3. EMBO J. 21 (2002) 324-333.
• 8. Lee, M.S., Kwon, Y.T., Li, M., Peng, J., Friedlander, R.M. and Tsai, L.H Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature 405 (2000) 360-364.
• 9. Nguyen, M.D., Lariviere, R.C. and Julien J.P. Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions. Neuron 30 (2001) 135-147.
• 10. Patrick, G.N., Zukerberg, L., Nikolic, M., de la Monte, S., Dikkes, P. and Tsai, L.H. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 402 (1999) 615-622.
• 11. Zheng, Y.L., Zukerberg, L., Nikolic, M., de la Monte, S., Dikkes, P. and Tsai, L.H. A peptide derived from cyclin-dependent kinase activator (p35) specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells. Eur. J, Biochem. 269 (2002) 4427-4434.