The graft-versus-host [GvH] reaction and experimental trichinellosis. I. Functional reactivities of T lymphocytes during experimental trichinellosis in irradiated mice developing the GvH reaction

• Autorzy: Bany J
• Języki publikacji: EN

Abstrakty

EN

The activity of splenocytes obtained from C3H/w mice during various phases of infection with T. spiralis was assessed using the GvH reaction in irradiated B6C3F₁ recipients of spleen cells. It was found that splenocytes obtained from mice during the intestinal phase of infection (i.e. on day 10 of infection) stimulated the GvH reaction whereas splenocytes obtained during later periods of infection (i.e. on days 20 or 30 of infection) inhibited the GvH reaction. The inhibitory effect persisted until day 60 of infection. Decreased function of T cells in the GvH reaction, as observed during the early muscle phase of trichinellosis (i.e. 30 days post injection of the larvae) was less pronounced in hosts infected with T. spiralis than in those infected with T. pseudospiralis. In addition, significant impairment of the GvH reaction was observed following the mixed transplant of splenocytes obtained from both uninfected C3H/w mice as well as from B6C3F₁ mice infected with T. pseudospiralis. The results indicate that the activity of T lymphocytes in mice infected with T. spiralis changes significantly during different phases of infection.

Słowa kluczowe

EN

irradiation; mouse; T lymphocyte; mice; trichinellosis; graft-versus-host disease

• Wydawca: -
• Czasopismo: Acta Parasitologica
• Rocznik: 1992
• Tom: 37
• Numer: 2
• Opis fizyczny: p.99-104,fig.

Twórcy

autor

Bany J

• Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-103 Warsaw, Poland

Bibliografia

• Bany J. 1983. Responsiveness of lymphocytes to PHA and ConA of mice infected with Trichinella spiralis or Trichinella pseudo-spiralis. Wiadomości Parazytologiczne, 29, 558-563.
• Barriga O.O. 1978. Depression of cell - mediated immunity following inoculation of Trichinella spiralis extract in the mouse. Immunology, 34, 167-173.
• Billingham R. E., Brent L. 1959. Quantitative studies in tissue transplantation immunity. IV. Induction of tolerance in newborn mice and studies on the phenomenon of runt disease. Transplantation of the Royal Society, London, Ser. B, 242, 439-447.
• Chimyshkyan K. L., Shakvatsabayna I. K., Ovumyan H. Sh., Babichev V. A., Trubcheninova L. P., Sorokina E. V., Svet-Moldavsky G. J. 1976. The effect of Trichinella spiralis on graft-versus-host reaction, transplantation immunity and antibody formation. Biomedicine, 25, 176-180.
• Elkins W. L. 1971. Cellular immunology and pathogenesis of graft- versus-host reaction. Progress of Allergy, 15, 78-187.
• Hilgard H. R. 1970. Dissociation of splenomegaly from graft-versus- host disease by host X-irradiation. Transplantation, 10, 396-402.
• Howard J. G., Michie D., Simonsen M. 1961. Splenomegaly as a host response in graft-versus-host disease. British Journal of Experimental Pathology, 42, 478-485.
• Karmańska K., Michalska Z., Mielczarek J., Ślaska B. 1987. Dynamika zmian immunopatologicznych w mięśniowej fazie włośnicy. Wiadomości Parazytologiczne, 33, 509-515.
• Korngold R., Sprent J. 1985. Surface markers of T cells causing lethal graft-versus-host disease to class I vs class II H-2 differences. Journal of Immunology, 135, 3005-3009.
• Krco J. Ch., David Ch. S., Wassom D. L. 1982. Characterization of an in vitro proliferation response to solubilized Trichinella spiralis antigens: Role of Ia antigens and Ly-1⁺ T cells. Immunology, 68, 359-367.
• Möller G. 1988. Do suppressor T cells exist? Scandinavian Journal of Immunology, 27, 247-250.
• Piquet P.F., Mercier A. J., Vassalli P., Saurat J. H. 1987. Epidermal lesions of the GvH evaluation of the role different MHC and non MHC loci and of the Ly-2⁺ and L3T4⁺ lymphocytes. Journal of Immunology, 139, 406-410.
• Rolink A. G., Gleichmann E. 1983. Allosuppressor and allohelper-T cells in acute and chronic graft-vs-host (GvH) disease. III. Different Lyt subsets of donor T cells induce different pathological syndroms. Journal of Experimental Medicine, 158, 346-358.
• Ruitenberg E. J., Elgersma A., Kruinziga W., Leenstra F. 1977. Trichinella spiralis infection in congenitally athymie (nude) mice: parasitological, serological and haematological studies with observations on intestinal pathology. Immunology, 33, 581-586.
• Simonsen M., Engelberth-Holm I., Jensen E., Paulsen H. 1958. Graft-versus-host reactivity. Annals of the New York Academy of Sciences, 73, 834-841.
• Skopińska E., Krzywicka E., Wichrzycka E., Zaleska-Rutyczyńska Z. 1976. Influence of the γ globulin fraction isolated from calf serum on graft-versus-host reaction in strongly histoincompatible mice. Archivum Immunologiae et Therapiae Experimentalis, 24, 383-389.
• Sprent J., Schafer M., Lo D., Korngold R. 1986. Functions of purified L3T4⁺ and Lyt-2⁺ cells in vitro and in vivo. Immunology Revue, 91,195-218.
• Tanner C. E., Lim H., Faubert C. 1978. Trichinella spiralis: Changes caused in mouse’s thymic splenic, and lymph node cell populations. Experimental Parasitology, 45, 116-127.
• Wakelin D. 1984. Evasion of the immune response: survival within low responder individuals of the host population. Parasitology, 88, 639-657.