Effect of cerebral ventricles perfusion with morphiceptin and met-enkephalin on trigemino-hypoglossal reflex in rats

• Autorzy: Zubrzycka M. , Fichna J. , Janecka A.
• Języki publikacji: EN

Abstrakty

EN

Opioids administered by intracerebroventricular injections produce analgesic responses in rats. The present study was undertaken to investigate the effects of a highly selective m-opioid receptor ligand morphiceptin on trigemino-hypoglossal reflex in rats. The analgesic effect of morphiceptin was compared with another opioid peptide, Met-enkephalin. With the experimental settings used in this study, we have demonstrated that both morphiceptin and Met-enkephalin show significant dose-dependent analgesic effects after i.c.v. administration in rats as assayed by trigemino-hypoglossal reflex test. The antinociceptive response to Met-enkephalin was short lasting and was observed 10 to 15 min after i.c.v. perfusion. Morphiceptin had a relatively longer duration of antinociceptive action, the effect was observed 20- 50 min after i.c.v. perfusion. Neither morphiceptin nor Met-enkephalin produced antinociception after peripheral injections. The results of the present study indicate that both tested peptides act at µ-opioid receptors situated in the central nervous system. They also suggest that µ-opioid receptors present in the central nervous system are an important element of the trigemino-hypoglossal reflex arc. For that reason selective m-opioid receptor ligands, like morphiceptin, inhibit the reflex more significantly.

Słowa kluczowe

EN

analgesic effect; cerebral ventricle; morphiceptin; intracerebroventricular injection; trigemino-hypoglossal reflex; met-enkephalin; perfusion; rat; opioid receptor

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2002
• Tom: 53
• Numer: 4,2
• Opis fizyczny: p.741-750,fig.

Twórcy

autor

Zubrzycka M.

• Medical University of Lodz, Lindleya 6, 90-131 Lodz, Poland

autor

Fichna J.

autor

Janecka A.