Protection of cattle against bovine leukemia virus [BLV] infection could be attained by DNA vaccination

• Autorzy: Brillowska A. , Dabrowski S. , Rulka J. , Kubis P. , Buzala E. , Kur J.
• Języki publikacji: EN

Abstrakty

EN

The bovine leukemia virus (BLV) envelope gene encoding extracellular glycoprotein gp51 and transmembrane glycoprotein gp30 was cloned into a vehicle expression vector under the human cytomegalovirus (CMV) intermediate early promoter. The intramuscular injection of this plasmid vector generated a cellular immune response. Seven out of ten cows vaccinated with the DNA construct resisted a drastic challenge (500 BLV-infected lymphocytes as an infectious dose).

Słowa kluczowe

EN

extracellular glycoprotein; enzootic bovine leukosis; DNA vaccination; infection; cattle; human cytomegalovirus; immunization; expression plasmid; protection; bovine leukemia virus; transmembrane glycoprotein

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1999
• Tom: 46
• Numer: 4
• Opis fizyczny: p.971-976,fig.

Twórcy

autor

Brillowska A.

• Technical University of Gdansk, G.Narutowicza 11-12, 80-952 Gdansk, Poland

autor

Dabrowski S.

autor

Rulka J.

autor

Kubis P.

autor

Buzala E.

autor

Kur J.

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