Structure, regulation and function of PKB-Akt - a major therapeutic target

• Autorzy: Hemmings B A
• Języki publikacji: EN

Słowa kluczowe

EN

function; structure; regulation; tyrosine kinase; protein kinase B; phosphoinositide; therapeutic target

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2003
• Tom: 08
• Numer: 2A
• Opis fizyczny: p.527

Twórcy

autor

Hemmings B A

• Friedrich Miescher-Institute, Maulbeerstrasse 66, 4002 Basel, Switzerland

Bibliografia

• 1. Brazil, D.P. and Hemmings, B.A. Ten years of PKB signaling: A hard Akt to follow. Trends Biochem. Sci. 26 (2001) 657-664.
• 2. Maira, S.M., Galetic, I., Brazil, D.P., Kaech, S., Ingley, E., Thelen, M. and Hemmings, B.A. C-terminal modulator protein (CTMP), a negative regulator of PKB and v-Akt localised to the plasma membrane. Science 294 (2001) 374-380.
• 3. Brazil D., Park, J. and Hemmings, B.A. PKB binding proteins: Getting in on the Akt. Cell 11 (2002) 293-303.
• 4. Hill, M.M., Feng, J., Cron, P. and Hemmings, B.A. Identification of a plasma membrane raft-associated PKB Ser473 kinase activity distinct from integrin-linked kinase and 3-phosphoinositide-dependent kinase-1. Curr. Biol. 12 (2002) 1251-1255.
• 5. Hill, M.M. and Hemmings, B.A. Inhibition of protein kinase B/Akt implications for cancer therapy. Pharmacol. Ther. 93 (2002) 1-9.
• 6. Yang, J., Cron, P., Thompson, V., Good, V.M., Hemmings, B.A. and Barford, D. The crystal structure of a PKB-GSK3 ternary complex. Nat. Struct. Biol. 9 (2002) 940-944.
• 7. Yang, J., Cron, P., Thompson, V., Good, V.M., Hess, D., Hemmings, B.A. and Barford, D. Structural basis for the regulation of protein kinase B/Atk by hydrophobic motif phosphorylation. Mol. Cell 9 (2002) 1227-1240.