Velocardiofacial syndrome [VCFS]: an important syndrome to recognize, caused by a microdeletion of chromosome 22q11

• Autorzy: Devriendt K , Swillen A , Frints S G M , Fryns J P
• Języki publikacji: EN

Abstrakty

EN

The phenotypic heterogeneity of the velocardiofacial syndrome (VCFS) or Shprintzen syndrome caused by a chromosomal 22q11 deletion will be discussed. The acronym ’CATCH22’ (Cardiac defects - Abnormal facies - Thymic hypoplasia - Cleft palate - Hypocalcaemia) has been suggested to indicate the associated phenotype. The variable clinical phenotype was previously recognized as DiGcorge syndrome and Shprintzen syndrome, but both are caused by a microdeletion of chromosome 22q11. However, most patients show only partial expression with mild clinical features. Through a sensitive genetic investigation called FISH (Fluorescence in situ hybridization) a diagnostic test of VCFS has become routinely possible, leading to an increased number of patients that are diagnosed. Early diagnosis is very important to recognize associated problems, to initiate adequate treatment and to provide necessary genetic counselling.

Słowa kluczowe

EN

facial dysmorphism; congenital heart defect; deletion; cleft palate; hypoplasia; velocardiofacial syndrome; chromosome 22q11; microdeletion; hypocalcaemia

• Wydawca: -
• Czasopismo: Journal of Applied Genetics
• Rocznik: 1997
• Tom: 38
• Numer: 1
• Opis fizyczny: p.87-102,fig.

Twórcy

autor

Devriendt K

• Centre for Human Genetics, Herestraat 49, B-3000 Leuven, Belgium

autor

Swillen A

• Centre for Human Genetics, Herestraat 49, B-3000 Leuven, Belgium

autor

Frints S G M

• Centre for Human Genetics, Herestraat 49, B-3000 Leuven, Belgium

autor

Fryns J P

• Centre for Human Genetics, Herestraat 49, B-3000 Leuven, Belgium

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