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Czasopismo

2005 | 64 | 4 |

Tytuł artykułu

Apoptosis in the course of experimental intracerebral haemorrhage in the rat

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Intracerebral haematoma was produced in 25 adult rats by infusion of 100 µl of autologous blood into the striatum. The animals’ brains were removed at 1, 3, 7, 14 and 21 days after production of the haematoma. The TUNEL method was used to detect DNA fragmentation and TUNEL-positive cells were qualified. TUNEL-positive cells were already found on the first day of observation and were present for three weeks after haematoma production. These results provide evidence that programmed cell death is associated with intracerebral haemorrhage.

Wydawca

-

Czasopismo

Rocznik

Tom

64

Numer

4

Opis fizyczny

p.248-252,fig.,ref.

Twórcy

autor
  • Medical University of Gdansk, Debinki 7, 80-211 Gdansk, Poland
autor
autor
autor

Bibliografia

  • 1. Acarin L, Gonzalez B, Castellano B (2001) Glial activation in the immature rat brain: implication of inflammatory transcription factors and cytokine expression. In: Castellano-Lopez B, Nieto-Sampedro M (eds.). Glial cell function. Elsevier, Amsterdam, London, New York, Oxford, Paris, Shanon, Tokyo, pp. 375–390.
  • 2. Altumbabic M, Peeling J, Del Bigio MR (1998) Intracerebral hemorrhage in the rat: effects of hematoma aspiration. Stroke, 29: 1917–1923.
  • 3. Broderick J, Brott T, Tomsick T, Tew J, Duldner J, Huster G (1994) Management of intracerebral hemorrhage in a large metropolitan population. Neurosurgery, 34: 882–887.
  • 4. Ferrer I, Tortosa A, Macaya A, Sierra A, Moreno D, Munell F, Blanco R, Squier W (1994) Evidence of nuclear DNA fragmentation following hypoxia-ischemia in the infant rat brain, and transient forebrain ischemia in the adult gerbil. Brain Pathol, 4: 115–122.
  • 5. Gong Ch, Boulis N, Qian J, Tuner DE, Hoff JT, Keep RF (2001) Intracerebral hemorrhage-induced neuronal death. Neurosurgery, 48: 875–882.
  • 6. Hermann DM, Mies G, Hata R, Hossmann K-A (2000) Microglial and astrocytic reactions prior to onset of thalamic cell death after traumatic lesion of the rat sensorimotor cortex. Acta Neuropathol, 99: 147–153.
  • 7. Holmin S, Mathiesen T (2000) Intracerebral administration of interleukin-1beta and induction of inflammation, apoptosis and vasogenic edema. J Neurosurg, 92: 108–120.
  • 8. Karwacki Z, Kowiański P, Dziewiatkowski J, Domaradzka-Pytel B, Ludkiewicz B, Wójcik S, Narkiewicz O, Moryś J (2005) The influence of sevoflurane on the reactivity of astrocytes in the course of experimental intracerebral haemorrhage in rat. J Physiol Pharmacol, 56: 455–469.
  • 9. Kowiański P, Karwacki Z, Dziewiątkowski J Domaradzka-Pytel B, Ludkiewicz B, Wójcik S, Litwinowicz B, Narkiewicz O, Moryś J (2003). Evolution of microglial and astroglial response during experimental intracerebral haemorrhage in the rat. Folia Neuropathol, 41: 123–130.
  • 10. Lisk DR, Pasteur W, Rhoades H (1994) Early presentation of hemispheric intracerebral hemorrhage: prediction of outcome and guidelines for treatment allocation. Neurology, 44: 133–139.
  • 11. Longe PA, Sriram S (1996) Regulation of microglial activation by TGF-beta, IL-10, and CSF-1. J Leucocyte Biol, 60: 502–508.
  • 12. Massague J (1990) The transforming growth factor-beta family Ann. Rev. Cell Biol, 6: 597–641.
  • 13. Otten U, Marz P, Heese K, Hock C, Kunz D, Rose-John S (2001) Signaling regulating neurotrophin expression in glial cells. In: Castellano-Lopez B, Nieto-Sampedro M (eds.). Glial cell function. Elsvier, Amsterdam, London, New York, Oxford, Paris, Shanon, Tokyo, pp. 545–554.
  • 14. Perry VH, Hume DA, Gordon S (1985) Immunohistochemical localization of macrophage and microglia in the normal adult mouse brain. Neuroscience, 15: 151–170.
  • 15. Qureshi AI, Ling GSF, Khan J, Suri FK, Miskolczi L, Guterman LR, Hopkins LN (2001) Quantitative analysis of injured, necrotic, and apoptotic cells in a new experimental model of intracerebral hemorrhage. Crit Care Med, 29: 152–152.
  • 16. Silva Y, Leira R, Tejada J, Lainez JM, Castillo J, Davalos A (2005) Molecular signatures of vascular injury are associated with early growth of intracerebral hemorrhage. Stroke, 36: 86–91.
  • 17. y Ribotta MG, Menet V, Privat A (2001) The role of astrocytes in axonal regeneration in the mammalian CNS. In: Castellano-Lopez B, Nieto-Sampedro M (eds.). Glial cell function. Elsevier, Amsterdam, London, New York, Oxford, Paris, Shanon, Tokyo, pp. 588–610.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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