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2008 | 49 | 1 |

Tytuł artykułu

Aberrant epigenetic patterns in the etiology of gastrointestinal cancers

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
A body of evidence accumulated over the past decade suggests that epigenetic mechanisms play an essential role in maintaining important cellular functions. Changes in epigenetic patterns (mainly DNA hyper- and hypomethylation and, more recently, histone modifications) may contribute to the development of cancer. Aberrant epigenetic events expand thorough tumor progression from the earliest to latest stages, therefore they can serve as convenient markers for detection and prognosis of cancer. The potential reversibility of epigenetic states in the tumor cell is an attractive target for cancer therapy. Much of our current knowledge on epigenetic alternations in cancer comes from studies on gastrointestinal malignancies, mainly on colorectal cancer, which currently serves as a model for epigenetic tumorigenesis. This review summarizes the current knowledge of epigenetic changes in gastrointestinal cancers and how this relates directly to disease progression and prognosis.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

49

Numer

1

Opis fizyczny

p.1-10,ref.

Twórcy

autor
  • Department of Genetics, Wroclaw Medical University, Marcinkowskiego 1, 50-368 Wroclaw, Poland
autor
  • Department of Genetics, Wroclaw Medical University, Marcinkowskiego 1, 50-368 Wroclaw, Poland
autor
  • Division of Molecular Genetics, Institute of Human Genetics, University of Tuebingen, Germany

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Bibliografia

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