Glycosaminoglycans of human serum and their alterations in diabetes mellitus

• Autorzy: Kozma E. M. , Olczyk K. , Glowacki A. , Komosinska K. , Sonecki P. , Najmiec T. , Jazwiec M.
• Języki publikacji: EN

Abstrakty

EN

Human serum contains several glycosaminoglycans (GAGs), mainly chondroitin sulphates and significantly less of heparan sulphate + heparin and dermatan sulphate. The non-insulin-dependent diabetes mellitus (with vascular complications) was associated with a significant increase in total serum GAG concentration, mainly of chondroitin sulphates and dermatan sulphate, with a simultaneous decrease in heparan sulphate + heparin level. These alterations were much more evident in patients with poor metabolic control. Hyaluronic acid (undetectable in healthy subjects and in patients with good metabolic control) appeared only in trace amounts in poorly controlled diabetic individuals. The obtained data allow to conclude that the diabetes mellitus-associated disturbances in tissue GAG metabolism lead to significant alterations in serum GAG composition.

Słowa kluczowe

EN

diabetic patient; human serum; glycosaminoglycan; diabetes; chondroitin sulphate; heparin

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1996
• Tom: 43
• Numer: 3
• Opis fizyczny: p.567-574,fig.

Twórcy

autor

Kozma E. M.

• Silesian Academy of Medicine, Jagiellonska 4, 41-200 Sosnowiec, Poland

autor

Olczyk K.

autor

Glowacki A.

autor

Komosinska K.

autor

Sonecki P.

autor

Najmiec T.

autor

Jazwiec M.

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