Beta 2-microglobulin and neopterin in patients with giardiasis

• Autorzy: Czarnowski D , Wiercinska-Drapalo A. , Prokopowicz D.
• Języki publikacji: EN

Abstrakty

EN

The aim of the study was to evaluate serum beta 2-microglobulin (beta-2m) and neopterin (NPT) in in patients with giardiasis. Twenty-two patients with giardiasis were examined and compared with twelve healthy subjects as a control group. Serum beta-2m and NPT concentration were determined twice: at the moment of diagnosis of giardiasis and six months after antiparasitic treatment with metronidazole. It was shown that serum beta-2m concentration in patients with giardiasis was remarkably elevated. It decreased significantly, but six months after treatment it was still higher as compared to the control group. However, serum NPT before antiparasitic treatment was slightly lower than in the control group, but after elimination of Giardia an increase of NPT concentration above control values was observed. It is concluded that Giardia infection leads to long-lasting disturbances in the immunological status of the host and may influence macrophage function and downregulate their parasiticidal effects.

PL

Celem pracy była ocena stężenia beta 2-mikroglobuliny (beta 2-m) i neopteryny (NPT) u pacjentów z giardiozą przed i po leczeniu przeciwpasożytniczym metronidazolem. Wykazano, że stężenie beta 2-m u chorych było podwyższone, a 6 miesięcy po leczeniu obniżało się, lecz nadal było wyższe niż w grupie kontrolnej. Natomiast stężenie NPT przed leczeniem przeciwpasożytniczym było niższe niż w grupie kontrolnej, a po eliminacji zarażenia obserwowano wzrost stężenia NPT powyżej wartości kontrolnych. Przeprowadzone badania wykazały, zarażenie Giardia intestinalis prowadzi do długotrwałych zaburzeń immunologicznych w organizmie gospodarza i może również mieć wpływ na przeciwpasożytnicze funkcje makrofagów.

Słowa kluczowe

EN

patient; neopterin; giardiasis; beta-2-microglobulin; intestinal infection

• Wydawca: -
• Czasopismo: Wiadomości Parazytologiczne
• Rocznik: 2000
• Tom: 46
• Numer: 4
• Opis fizyczny: p.487-492,fig.,ref.

Twórcy

autor

Czarnowski D

• Medical Academy of Bialystok, Zurawia 14, 15-540 Bialystok, Poland

autor

Wiercinska-Drapalo A.

autor

Prokopowicz D.

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