Fungal glycoproteins and their biosynthetic pathway as potential targets for antifungal agents

• Autorzy: Tanner W. , Gentzsch M. , Immervoll T. , Scheinost A. , Strahl-Bolsinger S.
• Języki publikacji: EN

Abstrakty

EN

The yeast cell wall as a good antifungal target is discussed in general. More specifically the reaction, catalyzed by Dol-P-Man: protein O-D-mannosyltransferase is proposed as a new potential target. Six genes responsible for this endoplasmic reticulum-localized reaction have been cloned and characterized so far. Triple dis­ruptions of these genes are either lethal or the corresponding cells have to be osmotically stabilized to survive. No inhibitors of this reaction are as yet known.

Słowa kluczowe

EN

yeast; glycoprotein; antifungal agent; fungal glycoprotein; O-D-mannosyltransferase; fungi; dolichyl phosphate; O-glycosylation; cell wall; fungal infection

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1995
• Tom: 42
• Numer: 4
• Opis fizyczny: p.505-508,fig

Twórcy

autor

Tanner W.

• University of Regensburg, 93040 Regensburg, Germany

autor

Gentzsch M.

autor

Immervoll T.

autor

Scheinost A.

autor

Strahl-Bolsinger S.

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