Menadione effect on L-cysteine desulfuration in U373 cells

• Autorzy: Wrobel M. , Jurkowska H.
• Języki publikacji: EN

Abstrakty

EN

The non-cytotoxic concentration (20 µM) of menadione (2-methyl-1,4-naphthoquinone), after 1 h of incubation, leads to loss of the activity of rhodanese by 33%, 3-mercaptopyruvate sulfurtransferase by 20%, as well as the level of sulfane sulfur by about 23% and glutathione by 12%, in the culture of U373 cells, in comparison with the control culture. Reactive oxygen species generated by menadione oxidize sulfhydryl groups in active centers of the investigated enzymes, inhibiting them and saving cysteine for glutathione synthesis. A decreased sulfane sulfur level can be correlated with an oxidative stress.

Słowa kluczowe

EN

U373 cell; 3-mercaptopyruvate sulphurtransferase; enzyme; menadione effect; oxidative stress; reactive oxygen species; sulphane sulphur; rhodanese

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2007
• Tom: 54
• Numer: 2
• Opis fizyczny: p.407-411,fig.,ref.

Twórcy

autor

Wrobel M.

• Jagiellonian University Medical College, M.Kopernika 7, 31-034 Krakow, Poland

autor

Jurkowska H.

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