Immunostimulative effects of repeated inhalation exposure to microvesicle-bound endotoxin of Pantoea agglomerans

• Autorzy: Dutkiewicz J. , Skorska C. , Burrell R. , Szuster-Ciesielska A. , Sitkowska J.
• Języki publikacji: EN

Abstrakty

EN

Rabbits exposed repeatedly to aerosols of endotoxin-containing microvesicles (ECMV) of the outer membrane of the Pantoea agglomerans strain isolated from airborne grain dust showed a large increase in the concentration of circulating cytokines: total interferon (IFN), interleukin-1 alpha (IL-1 alpha), and tumor necrosis factor alpha (TNF alpha). The increase was significantly higher compared to animals exposed to control saline (p<0.001). Aerosol exposure to ECMV also induced the formation of specific precipitin antibodies and lymphocyte activation. The results indicate strong immunomodulative properties of ECMVs produced in nature by Pantoea agglomerans bacteria, and heavily contaminating organic dusts.

Słowa kluczowe

EN

endotoxin; microvesicle; Pantoea agglomerans; inhalation exposure; interferon; interleukin 1alpha; tumour necrosis factor-alpha; cytokine; leucocyte migration; precipitin; plant surface; animal surface; organic dust; lung; inflammatory reaction; allergen

• Wydawca: -
• Czasopismo: Annals of Agricultural and Environmental Medicine
• Rocznik: 2005
• Tom: 12
• Numer: 2
• Opis fizyczny: p.289-294,fig.,ref.

Twórcy

autor

Dutkiewicz J.

• Institute of Agricultural Medicine, Jaczewskiego 2, 20-090 Lublin, Poland

autor

Skorska C.

autor

Burrell R.

autor

Szuster-Ciesielska A.

autor

Sitkowska J.

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