Zwiazek miedzy aktywnoscia hydrolaz grzybow wyizolowanych z pochwy kobiet ciezarnych i wybranymi objawami klinicznymi

• Autorzy: Nowakowska D , Kurnatowska A. , Wilczynski J.
• Języki publikacji: PL

Abstrakty

EN

Relationship between activity of hydrolases in fungi isolated from vagina of pregnant women and selected symptoms. Pregnancy is considered a factor of vulvovaginal mycosis. Secretion of hydrolases is an important determinant of Candida virulence. Thus, the aim of the study was to found the relationsbip between activity of 19 hydrolases in fungi isolated from vagina of pregnant women and symptoms of mycosis. 251 pregnant women were examined. Samples were collected from vagina and cultured on Sabouraud media. Activity of hydrolytic enzymes was evaluated using API ZYM (bioMerieux) test. Fungi were found in 20.1% of vaginal samples. Symptoms were detected in 45.8% of wornen. Only 32.1% of women with discharge and 26.4% with pruritus had mycosis. Out of the 19 examined hydrolazes, 13 active enzymes were detected in fungal strains. We found for the first time the relationsbip between activity of fungal esterase lipase and the presence of vaginal discharge in pregnant women.

Słowa kluczowe

PL

pochwa; grzyby; objawy kliniczne; zakazenia grzybicze; aktywnosc enzymatyczna; hydrolazy; parazytologia lekarska; kobiety ciezarne; izolaty grzybowe

• Wydawca: -
• Czasopismo: Wiadomości Parazytologiczne
• Rocznik: 2002
• Tom: 48
• Numer: 3
• Opis fizyczny: s.263-269,rys.,tab.,bibliogr.

Twórcy

autor

Nowakowska D

• Klinika Medycyny Matczyno-Plodowej, Instytut Centrum Zdrowia Matki Polski, Rzgowska 281/289, 93-338 Lodz

autor

Kurnatowska A.

autor

Wilczynski J.

Bibliografia

• Barrett-Bee K., Hayes Y., Wilson R.G. 1985. A comparison of phospholipase activity, cellular adherence and pathogenicity of yeasts. Journal of Genetic Microbiology 131: 1217-1221
• Calderone R.A., Fonzi W.A. 2001. Virulence factors in Candida albicans. Trends in Microbiology 9: 327- 334.
• Coth M.F., Hillier S.L., Gibbs R.S., Eschenbach D.A. 1998. Epidemiology and outcomes assiociated with moderate to heavy Candida colonization during pregnancy. American Journal of Obstetrics and Gynecology 178: 374-380.
• Eckert L.O., Hawes S.E., Stevens C.E., Koutsky L.A., Eschenbach D.A., Holmes K.K. 1998. Vulvovaginal candidasis: clinical manifestations, risk factors, management algorithm. Obstetrics and Gynecology 92: 757-765.
• Ghannoum M.A., Abu-Elteen K.H. 1990. Pathogenicity determinants of Candida. Mycoses 33: 265- 282.
• Gilstrap L.C., Faro S. 1997. Infections in Pregnancy. John Wiley = Sons Inc„ 39-46.
• Haynes K. 2001. Virulence in Candida species. Trends in Microbiology 9: 591-596.
• Kurnatowska A. 1961. Wykrywanie i oznaczanie grzybów występujących w pochwie kobiety. Ginekologia Polska 32: 44-50.
• Kurnatowska A. 1998. Biologia i ekologia grzybów chorobotwórczych. Grzybice narządów płciowych i moczowych. W: Zarys Mikologii lekarskiej. (Red. E. Baran), Volumed, Wrocław.
• MacDonald F., Odds F.C. 1980. Inductible proteinase of Candida albicans in diagnostic serology and in the pathogenesis of systemic candidosis. Journal of Medical Microbiology 13: 423-435.
• Mailliot K., Rummel W., Kleissl P. 1978. Candida mycosis in pregnant women and related risks to the newborn. Mycosen l(Suppl): 246-251.
• Nowakowska D. 2001. Charakterystyka cech gatunkowych i wewnątrzgatunkowych grzybów wyodrębnionych z inwazji wieloogniskowych kobiet ciężarnych z cukrzycą,. Praca doktorska, A.M. Łódź.
• Odds F.C. 1979. Candida and Candidosis. Leicester University Press.
• Ogawa H., Tsuobi R. 1997. Fungal enzymes related to the pathogenesis of mycoses. In: Fungal Disease: Biology, Immunology and Diagnosis. (Eds. Jackobs P.H., Nail L. Marcel Dekker), New York, 191-207.
• Reed B.D. 1992. Risk factors for Candida vulvovaginitis. Obstetrical and Gynecological Survey 47: 551- S(i().
• Sobel J.D. 1989. Pathophysiology of vulvovaginitis candidiasis. Journal of Reproductive Medicine 34: 572-579.
• Tobin M.J. 1995. Vulvovaginal candidiasis: Topical vs. oral therapy. American Family Phisician 51: 1715-1720.