Peripheral mechanisms of intestinal dysmotility in rats with salsolinol induced experimental Parkinson's disease

• Autorzy: Banach T. , Zurowski D. , Gil K. , Krygowska-Wajs A. , Marszalek A. , Thor P.J.
• Języki publikacji: EN

Abstrakty

EN

Gastrointestinal dysmotility in Parkinson's disease (PD) has been attributed in part to peripheral neurotoxine action. Our purpose was the evaluation of the salsolinol effect on intramuscular interstitial cells of Cajal (ICC), duodenal myoelectrical activity (DMA) and vagal afferent activity (VAA) in rats with experimental PD. Twenty rats were divided into 2 equal groups. Experimental PD was produced in one group by 3 weeks of the intraperitoneal salsolinol injections (50 mg/kg/day), whereas the 2-nd group served as control. DMA and VAA were recorded in both groups during fasting and stepwise - gastric distension (GD) of 10 ml. Subsequently fragments of duodenum were removed and intramuscular ICC were assessed as c-Kit antigen percentage in the duodenal muscular zone. Analyses of the fasting DMA and VAA recordings didn't reveal differences between the compared groups. During GD increase of DMA dominant frequency (p=0.04) and VAA frequency (p<0.01) was observed in the controls whereas in the salsolinol group both parameters remained unchanged. Image analysis of duodenum revealed decreased c-Kit expression in the salsolinol-injected animals (p=0.05). The results of our study may suggest the direct effect of salsolinol on both ICC and neuronal pathways of gastro-duodenal reflexes.

Słowa kluczowe

EN

vagus afferent activity; gastric distension; interstitial cell; myoelectrical activity; salsolinol; rat; peripheral mechanism; Parkinson's disease; intestinal dysmotility

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2006
• Tom: 57
• Numer: 2
• Opis fizyczny: p.291-300,fig.,ref.

Twórcy

autor

Banach T.

• Jagiellonian University Medical College, Czysta 18, 31-121 Krakow, Poland

autor

Zurowski D.

autor

Gil K.

autor

Krygowska-Wajs A.

autor

Marszalek A.

autor

Thor P.J.