Potential role of LPS in the outcome of Helicobacter pylori related diseases

• Autorzy: Grebowska A , Rechcinski T. , Bak-Romaniszyn L. , Czkwianianc E. , Moran A. , Druszczynska M. , Kowalewicz-Kulbat M. , Owczarek A. , Dziuba M. , Krzeminska-Pakula M. , Planeta-Malecka I. , Rudnicka W. , Chmiela M.
• Języki publikacji: EN

Abstrakty

EN

In this study we asked a question whether H. pylori LPS with or without LewisXY (Le) determinants as well as LBP (lipopolysaccharide binding protein) and sCD14 molecules recognizing bacterial LPS may be involved in atherogenesis. Sera from 57 patients with coronary heart disease (CHD), 27 H. pylori infected dyspeptic patients-H.p.(+) and 49 healthy controls (HC) were tested for IgM and IgG to H. pylori LPS expressing LeX (LPS LeX) or LeXY (LPS LeXY) determinants and to a glycine acid extract (GE). Immune complexes (ICs) of Lewis antigens and specific IgM or IgG were also determined. The prevalence of anti-GE IgG and IgA was significantly higher in CHD as compared to HC and the same as in the H.p.(+) group. The highest levels of anti-GE IgG were detected only for CHD group. CHD patients showed upregulation of IgG to LPS LeX and LeXY. In contrast, an upregulation of IgM to such LPSs was found for healthy subjects. The levels of LeY-anti-LeY IgG ICs were higher in CHD patients than in healthy controls similarly to the levels of LBP. There was no difference in sCD14 concentration between CHD and HC groups. The results obtained in this study indicate that H. pylori infections may be the risk factors of atherosclerosis due to: 1) an enhanced humoral response to H. pylori surface antigens, 2) a host predisposition to respond to Lewis determinants present in H. pylori LPS by IgG, 3) increased levels of serum LBP.

Słowa kluczowe

EN

Chlamydia pneumoniae; human disease; coronary heart disease; bacteria; microbiology; gastroduodenal ulcer disease; Helicobacter pylori; pathology

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2006
• Tom: 55
• Numer: 1
• Opis fizyczny: p.25-30,ref.

Twórcy

autor

Grebowska A

• University of Lodz, Banacha 12/16, 90-237 Lodz, Poland

autor

Rechcinski T.

autor

Bak-Romaniszyn L.

autor

Czkwianianc E.

autor

Moran A.

autor

Druszczynska M.

autor

Kowalewicz-Kulbat M.

autor

Owczarek A.

autor

Dziuba M.

autor

Krzeminska-Pakula M.

autor

Planeta-Malecka I.

autor

Rudnicka W.

autor

Chmiela M.

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