Influence of nonselective ETA-ETB receptor blockade on renal function in conscious rats: effects of renal denervation

• Autorzy: Girchev R. , Markova P. , Vuchidolova V.
• Języki publikacji: EN

Abstrakty

EN

The effects of nonselective ETA/ETB receptor blockade with intravenous bolus injection of bosentan (10 mg/kg) on renal excretory function and blood pressure were investigated in conscious, male, normotensive Wistar rats before and one week after bilateral renal denervation. Renal denervation was followed by an increase in urine flow rate from 4.54±0.38 to 5.72±0.36 µl/min.100 g b.w. (p<0.05) and a decrease in urine osmolality from 855.5±44.6 to 707.4±47.5 mosm/kg H2O (p<0.05). Bosentan administration in sham-operated rats resulted in decrease in urine flow rate from 4.54±0.38 to 3.49±0.34 µl/min.100 g b.w. (p<0.05), and increase in urine osmolality from 855.5±44.6 to 1075.0±76.1 mosm/kg H2O (p<0.05). Sodium excretion decreased from 226.9±20.0 to 155.1±11.0 nmol/min.100 g b.w. (p<0.01). Bosentan administration in renal denervated rats did not produce any changes in renal water or electrolyte excretions. Blood pressure, heart rate, clearance of Inulin or clearance of paraaminohippuric acid (PAH) did not change in sham-operated or renal denervated rats during nonselective ETA/ETB receptor blockade. Bosentan did not alter the baroreflex sensitivity or sympatho-vagal balance in sham-operated or renal denervated rats. In conclusion, an interaction between renal nerves and endothelins appears to be involved in the regulation of the renal excretory function.

Słowa kluczowe

EN

renal denervation; receptor; endothelin; renal excretory function; rat

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2004
• Tom: 55
• Numer: 2
• Opis fizyczny: p.381-389,fig.,ref.

Twórcy

autor

Girchev R.

• Medical University, 2 Zdrave str., Sofia 1431, Bulgaria

autor

Markova P.

autor

Vuchidolova V.