Nienasycone kwasy tluszczowe omega-3 a rozwoj i funkcjonowanie osrodkowego ukladu nerwowego

• Autorzy: Ciok J

Warianty tytułu

EN

Omega-3 long-chain polyunsaturated acids - their influence on development and functioning of central nervous system

• Języki publikacji: PL

Abstrakty

PL

W pracy dokonano przeglądu badań dotyczących wpływu długołańcuchowych wielonienasyconych kwasów tłuszczowych (PUFA), a zwłaszcza kwasów omega-3, których głównym przedstawicielem jest kwas dokozaheksaenowy (DHA), na rozwój psychoruchowy w okresie płodowym i okresie wczesnego dzieciństwa. Różnorodne badania wskazują na wpływ stężenia DHA w ośrodkowym układzie nerwowym na wyniki testów oceniających rozwój psychoruchowy. Wpływ ten jest jednak dość dobrze udokumentowany tylko w odniesieniu do życia płodowego i okresu karmienia piersią. Istnieje potrzeba przeprowadzenia badań, których zadaniem będzie potwierdzenie, czy ta zależność ma charakter przyczynowo-skutkowy.

EN

The goal of the review is to provide an overview of human and animal studies that link the availability during development of the long-chain polyunsaturated fatty acids (LCPUFAs), particularly the n-3 LCPUFA docosahexaenoic acid (DHA), to performance on cognitive or behavioral tests during fetal and child development period. Data coming from several types of studies suggests that changes in brain concentrations of DHA are positively associated with changes in cognitive or behavioral performance, but it is well confirmed only for fetal and breastfeeding period. Additional experimental data is required to conclude that a causal-effect association exists.

Słowa kluczowe

PL

zywienie czlowieka; kwasy tluszczowe wielonienasycone; kwasy tluszczowe omega-3; rozwoj psychomotoryczny; uklad nerwowy osrodkowy; uczenie sie; kwas dekozaheksaenowy; okres plodowy; karmienie piersia

• Wydawca: -
• Czasopismo: Żywienie Człowieka i Metabolizm
• Rocznik: 2008
• Tom: 35
• Numer: 3
• Opis fizyczny: s.247-257,bibliogr.

Twórcy

autor

Ciok J

• Zakład Dietetyki i Żywienia Klinicznego, Instytut Zywnosci i Zywienia, Warszawa

Bibliografia

• 1. Auestad N., Halter R., Hall R.T., et al.: Growth and development in term infants fed long- chain polyunsaturated fatty acids: a double-masked, randomized, parallel, prospective, multivariate study. Pediatrics 2001, 108, 372-381.
• 2. Bakker E.C., Ghys A.J.A., Kester A.D.M., et al..: Long-chain polyunsaturated fatty acids at birth and cognitive function at 7 y of age. Eur. J. Clin. Nutr., 2003,57,89-95.
• 3. Beblo S., Reinhardt H., Muntau A.C., et al.: Fish oil supplementation improves visual evoked potentials in children with phenylketonuria. Neurology 2001,57,1488-1491.
• 4. Ben X.M., Zhou X.Y., Zhao W.H., et al.: Growth and development of term infants fed with milk with long- chain polyunsaturated fatty acid supplementation. Chin. Med. J., 2004,117,1268-1270.
• 5. Bergmann R.L., Haschke-Becher E., Klassen-Wigger P., et al.: Supplementation with 200 mg/day docosahesaenoic acid from mid-pregnancy through lactation improves the docosahesaenoic acid status of mothers with habitually low fish intake and of their infants. Ann. Nutr. Metab., 2008, 52, 157-166.
• 6. Birch E.E., Castaneda Y.S., Wheaton D.H., et al.: Visual maturation of term infants fed long-chain polyunsaturated fatty acid-supplemented or control formula for 12 mo. Am. J. Clin. Nutr., 2005, 81, 871-879.
• 7.Bouwstra H., Dijck-Brouwer D.A., Wildeman J.A., et al.: Long-chain polyunsaturated fatty acids have a positive effect on the quality of general movements of healthy term infants. Am. J. Clin. Nutr., 2003,78,313-318.
• 8. Clandinin M.T., Chappell J.E., Leong S., et ah: Extrauterine fatty acid accretion in infant brain: implications for fatty acid requirements. Early Hum. Dev., 1980, 4, 131-138.
• 9. Clandinin M.T., Van Aerde J.E., Merkel K.L., et al.: Growth and development of preterm infants fed infant formulas containing docosahexaenoic acid and arachidonic acid. J. Pediatr., 2005, 146, 461-468.
• 10. Dunstan J.A., Simmer K., Dixon G., Prescott S.L.: Cognitive assessment of children at age 2 1/2 years after maternal fish oil supplementation in pregnancy: a randomized controlled trial. Arch. Dis. Child Fetal Neonatal Ed., 2008,93, F45-F50.
• 11. Fang P.C., Kuo H.K., Huang C.B., et al.: Ihe effect of supplementation of docosahexaenoic acid and arachidonic acid on visual acuity and neurodevelopment in larger preterm infants. Chang Gung. Med. J., 2005, 28, 708-715.
• 12. Fewtrell M.S., Abbott R.A., Kennedy K., et al.: Randomized, double-blind trial of long-chain polyunsaturated fatty acid supplementation with fish oil and borage oil in preterm infants. J. Pediatr., 2004, 144, 471-479.
• 13. Haag M.: Essential fatty acids and the brain. Can. J. Psychiatry., 2003, 48, 195-203.
• 14. Heiland I.B., Saugstad O.D., Smith L., et al.: Similar effects on infants of n-3 and n-6 fatty acids supplementation to pregnant and lactating women. Pediatrics 2001, 108, E82.
• 15. Helland I.B., Smith L., Saarem K., et al.: Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children IQ at 4 years of age. Pediatrics 2003, 111, 39-44.
• 16. Hibbeln J.R., Davis J.M., Steer C., et al.: Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study. Lancet 2007, 369, 578-585.
• 17. Hirayama S., Hamazaki T., Terasawa K.: Effect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit/hyperactivity disorder - a placebo-controlled double-blind study. Eur. J. Clin. Nutr., 2004, 58, 467-473.
• 18. Hoffman D.R., Theuer R.C., Castaneda Y.S., et al.: Maturation of visual acuity is accelerated in breast-fed term infants fed baby food containing DHA-enriched egg yolk. J. Nutr., 2004, 134, 2307-2313.
• 19. Innis S.M.: Fatty acids and early human development. Early Hum. Dev., 2007, 83, 761-766.
• 20. Jacobson J.L., Jacobson S.W., Muckle G. et al.: Beneficial effects of a poluunsaturated fatty acid on infant development: evidence from the inuit of arctic Quebec. J. Pediatr., 2008,152, 356-364.
• 21. Jensen C.L., Voight R.G., Prager T.C., et al.: Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment in breastfed term infants. Am. J. Clin. Nutr., 2005, 82, 125-132.
• 22. Judge M.P., Harel O., Lammi-Keefe C.J.: Maternal consumption of a docosahexaenoic acid-containing functional food during pregnancy: benefit for infant performance on problem-solving but not on recognition memory tasks at age 9 mo. Am. J. Clin. Nutr., 2007, 85, 1572-1577.
• 23. Lauritzen L., Jorgensen M.H., Olsen S.F., et al.: Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants. Reprod. Nutr. Dev., 2005,45,535-547.
• 24. Malcolm C. A., Hamilton R., McCulloch D.L., et al.: Scotopic electroretinogram in term infants born of mothers supplemented with docosahexaenoic acid during pregnancy. Invest. Ophtalm. Vis. Sci., 2003, 44, 3685-3691.
• 25. Malcolm C.A., McCulloch D.L., Montgomery C., et al.: Maternal docosahexaenoic acid supplementation during pregnancy and visual evoked potential development in term infants: a double blind, prospective, randomized trial. Arch. Dis. Child Fetal Neonatal Ed., 2003,88, F383-390.
• 26. Martinez M.: Tissue levels of polyunsaturated fatty acids during early human development. J. Pediatr., 1992,120, S129-S138.
• 27. McCann J.C., Ames B.N.: Is docosaheaxaenoic acid, an n-3 log-chain polyunsaturated fatty acid, required for normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. Am. J. Clin. Nutr., 2005, 82, 281-295.
• 28. Morale S.E., Hoffman D.R., Castaneda Y.S., et al.: Duration of long- chain polyunsaturated fatty acids availability in the diet and visual acuity. Early Hum. Dev., 2005, 81, 197-203.
• 29. Oken E., Radesky J.S., Wright R.O., et al.: Maternal fish intake during pregnancy, blood mercure levels, and child cognition at age 3 years in a US cohort. Am. J. Epidemiol., 2008,167,1171-1181.
• 30. Oken E., Wright R.O., Kleinman K.P., et al.: Maternal fish consumption, hair mercury, and infant cognition in a U.S.cohort. Envir. Health Perspect., 2005,113,1376-1380.
• 31. Richardson A.J., Montgomery P.: The Oxford-Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics 2005, 115, 1360-1366.
• 32. Richardson A.J., Puri B.K.: A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2002, 26, 233-239.
• 33. Richardson AJ.: Clinical trials of fatty acid treatment in ADHD, dyslexia, dyspraxia and the autistic spectrum. Prostaglandins Leukot Essent Fatty Acids 2004, 70, 383-390.
• 34. Simmer K., Patole S.: Longchain polyunsaturated fatty acid supplementation in preterm infants. Cochrane Database Syst. Rev., 2004,1, CD000375.
• 35. Stevens L., Zhang W., Peck L., et al.: EFA supplementation in children with inattention, hyperactivity, and other disruptive behaviors. Lipids 2003, 38, 1007-1021.
• 36. Tofail F., Kabir I., Hamadani J.D., et al.: Supplementation of fish-oil and soy-oil during pregnancy and psychomotor development of infants. J. Health Popul. Nutr., 2006, 24,48-56.
• 37. Uauy R., Hoffman D.R., Mena P., et al.: Term infant studies of DHA and ARA supplementation on neurodevelopment: results of randomized controlled trials. J. Pediatr., 2003,143, S17-S25.
• 38. Unay B., Sarici S.U., Ulas U.H., et al.: Nutritional effects on auditory brainstem maturation in healthy term infants. Arch. Dis. Child. Fetal Neonatal Ed., 2004, 89, F177-F178.
• 39. Yehuda S.: Omega-6/omega-3 ratio and brain-related functions. World Rev. Nutr. Diet., 2003, 92, 37-56.
• 40. Zhang J., Hebert J.R., Muldoon M.F.: Dietary fat intake is associated with psychosocial and cognitive functioning of school-aged children in the United States. J. Nutr., 2005,135,1967-1973.