Comparative studies of experimental giardiasis in Mongolian gerbils. III. Changes in small intestine induced with human and zoo animal Giardia isolates

• Autorzy: Majewska A C , Gustowska L
• Języki publikacji: EN

Abstrakty

EN

Four groups of gerbils, each consisting of nine animals, were inoculated with 10⁵ viable cysts of four Giardia isolates obtained from human and from zoo animals. The infected and control gerbils were killed on 7 and 21 day post infection and on 21 day post patent period of infection. This study showed that Giardia isolates recovered from different host species have various potency of inducing changes in the jejunum of gerbils and that the primary host imprinting on Giardia isolate may play an important role in the parasite’s behaviour in other host species. The earliest significant changes were observed in the jejunum of gerbils infected with Giardia obtained from a symptomatic patient. Noteworthy changes were found in the 3 week of infection: (1) the jejunal villi were shortened in gerbils infected with human Giardia isolates, and were elongated in animals infected with rodents Giardia isolates; (2) Giardia obtained from an asymptomatic person induced statistically significant changes in all the parameters of the gerbils’ jejunum except infiltration of the lamina propria; (3) although diarrhoea occurred in gerbils infected with Giardia from a cuis, there were no significant changes except the elongation of the villi and infiltration of lamina propria. The four Giardia isolates induced various mucosal mast cells responses in gerbils. Despite the three- weaks-earlier spontaneous ceasing of the infection caused by animal Giardia isolates, the changes in the jejunum persisted.

Słowa kluczowe

EN

parasite; Mongolian gerbil; isolate; infection; man; cyst; jejunum; giardiasis; animal; gerbil; Giardia isolate

• Wydawca: -
• Czasopismo: Acta Parasitologica
• Rocznik: 1996
• Tom: 41
• Numer: 3
• Opis fizyczny: p.128-135,fig.

Twórcy

autor

Majewska A C

• Department of Biology and Medical Parasitology, Karol Marcinkowski University of Medical Sciences, Fredry 10, 61-701 Poznan, Poland

autor

Gustowska L

• Department of Clinical Pathomorphology, Karol Marcinkowski University of Medical Sciences, Fredry 10, 61-701 Poznań, Poland

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