Grelina-obestatyna - nowy mechanizm regulacji laknienia?

• Autorzy: Oclon E , Pietras M.

Warianty tytułu

EN

Ghrelin-Obestatin: a new mechanism for appetite control?

• Języki publikacji: PL

Abstrakty

EN

Ghrelin and obestatin are encoded by the same gene and originate from posttranslational processing of the preproghrelin peptide. The activities of ghrelin and obestatin are different. The effects of obestatin on feeding behavior, body weight regulation are the opposite to those of ghrelin. Administration of ghrelin increases food intake, while, contrarily, the systemic and central administration of obestatin inhibits feeding. Ghrelin and obestatin interact with two distinct subtypes of G-protein-coupled receptor: GHS-R and GPR 39

Słowa kluczowe

PL

gen ghrl; fizjologia zwierzat; pobieranie pokarmu; grelina; obestatyna; regulacja

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2007
• Tom: 63
• Numer: 10
• Opis fizyczny: s.1139-1141,rys.,bibliogr.

Twórcy

autor

Oclon E

• Instytut Zootechniki - Panstwowy Instytut Badawczy, ul.Krakowska 1, 32-083 Balice

autor

Pietras M.

Bibliografia

• 1.Bresciani E., Rapetti D., Dona F., Bulgarelli I., Tamiazzo L., Locatelli V., Torsello A.: Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat. J. Endocrinol. Invest. 2006, 29, RC16-18.
• 2.Brobeck J. R.: Identity of hypothalamic feeding mechanisms. J. Neurovisc. Relat. 1971, Suppl. 10, 277-281.
• 3.Chanoine J. P., Wong A. C., Barrios V.: Obestatin, acylated and total ghrelin concentrations in the perinatal rat pancreas. Horm. Res. 2006, 66, 81-88.
• 4.Dun S. L., Brailoiu G. C., Brailoiu E., Yang J., Chang J. K., Dun N. J.: Distribution and biological activity of obestatin in the rat. J. Endocrinol. 2006, 191, 481-489.
• 5.Garcia A., Alvarez C. V., Smith R. G., Dieguez C.: Regulation of Pit-1 expression by ghrelin and GHRL-6 through the GH secretagogue receptor. Mol Endocrinol. 2001, 15, 1484-1495.
• 6.Goto M., Arima H., Watanabe M., Hayashi M., Banno R., Sato I., Nagasaki H., Oiso Y.: Ghrelin Increases Neuropeptide Y and Agouti-Related Peptide Gene Expression in the Arcuate Nucleus in Rat Hypothalamic Organotypic Cultures. Endocrinology 2006, 147, 5102-5109.
• 7.Gualillo O., Lago F., Casanueva F. F., Dieguez C.: One ancestor, several peptides post-translational modifications of preproghrelin generate several peptides with antithetical effects. Mol. Cell Endocrinol. 2006, 256, 1-8.
• 8.Hosoda H., Kojima M., Matsuo H., Kangawa K.: Purification and characterization of rat des-Gln14-Ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor. J. Biol. Chem. 2000, 275, 21995-20000.
• 9.Jackson V. R., Nothacker H. P., Civelli O.: GPR39 receptor expression in the mouse brain. Neuroreport. 2006, 17, 813-816.
• 10.Jeffery P. L., Duncan R. P., Yeh A. H., Jaskolski R. A., Hammond D. S., Herington A. C., Chopin L. K.: Expression of the ghrelin axis in the mouse: an exon 4-deleted mouse proghrelin variant encodes a novel C terminal peptide. Endocrinology 2005, 146, 432-440.
• 11.Kaiya H., Kojima M., Hosoda H., Koda A., Yamamoto K., Kitajima Y., Matsumoto M., Minamitake Y., Kikuyama S., Kangawa K.: Bullfrog ghrelin is modified by n-octanoic acid at its third threonine residue. J. Biol. Chem. 2001, 276, 40441-40448.
• 12.Kaiya H., Van Der Geyten S., Kojima M., Hosoda H., Kitajima Y., Matsumoto M., Geelissen S., Darras V. M., Kangawa K.: Chicken ghrelin: purification, cDNA cloning, and biological activity. Endocrinology 2002, 143, 3454-3463.
• 13.Kamegai J., Tamura H., Shimizu T., Ishii S., Shugihara H., Wakabayashi I.: Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats. Diabetes 2001, 50, 2438-2443.
• 14.Kojima M., Haruno R., Nakazato M., Date Y., Murakami N., Hanada R., Matsuo H., Kangawa K.: Purification and identification of Neuromedin U as an endogenous ligand for an orphan receptor GPR66 (FM3). Biochem. Biophysic. Research Communications 2000, 276, 435-438.
• 15.Kojima M., Hosoda H., Date Y., Nakazato M., Matmo H., Kangawa K.: Ghrelin is a growth hormone-releasing acylated peptide from stomach. Nature 1999, 402, 656-660.
• 16.Lengyel A. M.: Novel mechanisms of growth hormone regulation: growth hormone-releasing peptides and ghrelin. Braz. J. Med. Biol. Res, 2006, 39, 1003-1011 (Review).
• 17.McKee K. K., Tan C. P., Palyha O. C., Liu J., Feighner S. D., Hreniuk D. L., Smith R. G., Howard A. D., Van der Ploeg L. H.: Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors. Genomics 1997, 46, 426-434.
• 18.Nogueiras R., Tschop M.: Biomedicine. Separation of conjoined hormones yields appetite rivals. Science 2005, 310, 985-986.
• 19.Pemberton C., Wimalasena P., Yandle T., Soule S., Richards M.: C-terminal pro-ghrelin peptides are present in the human circulation. Biochem. Biophys. Res. Commun. 2003, 15, 1484-1495.
• 20.Smith R. G., Feighner S., Predergast K., Guan X., Howard A.: A New Orphan Receptor Involved in Pulsative Growth Hormone Release. Trends Endocrinol. Metab. 1999, 10, 128-135.
• 21.Sun Y., Ahmed S., Smith R. G.: Deletion of ghrelin impairs neither growth nor appetite. Moll. Cell. Biol. 2003, 23, 7973-7981.
• 22.Tanaka M., Hayashida Y., Nakao N., Nakai N., Nakashima K.: Testis-specific and develomentally induced expression of a ghrelin gene-derived transcript that encodes a novel polypeptide in the mouse. Biochim. Biophys. Acta. 2001, 1522, 62-65.
• 23.Yeh A. H., Jeffery P. L., Duncan R. P., Herington A. C., Chopin L. K.: Ghrelin and a novel preproghrelin isoform are highly expressed in prostate cancer and ghrelin activates mitogen-activated protein kinase in prostate cancer. Clin. Cancer Res. 2005, 11, 8295-8303.
• 24.Zhang J. V., Ren P. G., Avsian-Kretchmer O., Luo C. W., Rauch R., Klein C., Hsueh A. J.: Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake. Science 2005, 310, 996-999.