Cholinergic innervation of parvalbumin- and calbindin-containing neurones in the hippocampus during postnatal development of the rat brain

• Autorzy: Ludkiewicz B , Wojcik S. , Spodnik E. , Domaradzka-Pytel B. , Klejbor I. , Morys J.
• Języki publikacji: EN

Abstrakty

EN

Immunohistochemical study of the cholinergic innervation of the parvalbuminand calbindin-containing cells in the hippocampus was conducted on 30 rat brains of various postnatal ages: P0, P4, P7, P14, P21, P30, P60 and P180. Sections with double immunostaining for vesicular acetylcholine transporter (VAChT; the marker of cholinergic cells, fibres and terminals) and parvalbumin (PV) or calbindin (CB) were analysed using confocal laser-scanning microscope. Obtained data demonstrate that the pattern of cholinergic innervation of calbindin- and parvalbumin-immunoreactive hippocampal neurones shows some differences. During development as well as in the adult species cholinergic terminals preferentially innervate CB-containing neurones, while cholinergic terminals on PV-containing cells were observed rarely. Cholinergic endings on the CB-ir neurones are localised both on their somata and dendrites, whereas on PV-ir cells they form synaptic contact predominantly with processes. In spite of the unquestionable cholinergic influence particularly on CB-ir cells, the number of cholinergic endings suggests that this input seems not to be crucial for the activity of the studied cell populations.

Słowa kluczowe

EN

hippocampus; development; calbindin; parvalbumin; cholinergic system; innervation; neuron; rat; brain; postnatal development

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2002
• Tom: 61
• Numer: 2
• Opis fizyczny: p.89-96,fig.,ref.

Twórcy

autor

Ludkiewicz B

• Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland

autor

Wojcik S.

autor

Spodnik E.

autor

Domaradzka-Pytel B.

autor

Klejbor I.

autor

Morys J.

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