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2007 | 51 | 1 |

Tytuł artykułu

Levels of some blood diagnostic indices in young cattle with different genotypes at the alpha-lactalbumin locus

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The aim of the present study was to verify the hypothesis that α-lactalbumin (LALBA) gene polymorphism may be a factor differentiating defence mechanisms in cattle. The association between LALBA polymorphism and the levels of blood indices characterising defence functions were examined in a group of 129 female calves and young heifers, produced by random mating of parental couples. The levels of blood diagnostic indices were determined four times: at 15 to 30 d, 3 months, 6 months, and 12 months of age. The genotypes distribution within the progeny was uneven (LALBA AA - 59.7%, LALBA AB - 35.7%, LALBA BB - 4.6%). At all times of the analysing, statistically significant differences between LALBA genotype groups were observed in the number of leukocytes (LALBA AA>LALBA BB), and the percentage of eosinophils (LALBA BB> LALBA AA). LALBA polymorphism also differentiated the percentages of lymphocytes (15 to 30 d, 3 months), neutrophils (15 to 30 d, 3 months, 12 months), basophils (6 and 12 months), and monocytes (6 months). Differences in the levels of total protein and γ-globulin were relatively low in animals aged 15 to 30 d, 3 months, and 6 months, but high in those aged 12 months (LALBA AB>LALBA AA>LALBA BB). There was a correlation between LALBA polymorphism and lysozyme activity (LALBA AA>LALBA AB> LALBA BB). Higher values of the NBT reduction tests were recorded in calves aged 15 to 30 d, as compared with older ones.

Wydawca

-

Rocznik

Tom

51

Numer

1

Opis fizyczny

p.97-103,ref.

Twórcy

  • University of Warmia and Mazury, 10-718 Olsztyn, Poland
autor
autor
autor

Bibliografia

  • 1. Bleck G.T., Bremel R.: Sequence and single-base polymorphism of the bovine α-lactoalbumin 5'-flanking region. Gene 1993, 126, 213-218.
  • 2. Browne W.J., North A.C.T., Phillips D.C.: A possible three-dimensional structure of bovine α-lactalbumin based on that of hen's egg-white lysozyme. J Mol Biol 1969, 42, 65-86.
  • 3. Caffini J.P., Poutrel B., Rainard P.: Physiological and pathological factors influencing bovine µ-lactoalbumin and ß-lactoglobulin concentrations in milk. J Dairy Sci 1985, 68, 1087-1094.
  • 4. Hakansson A., Svensson M., Mosseberg A.K., Sabharwal H., Linse S., Lazuou I., Lönnrdal B., Svanborg C.: A folding variant α-lactalbumin with bactericidal activity against Streptococcus pneumoniae. Mol Microbiol 2000, 35, 589-600.
  • 5. Haviv Y.S., Curiel D.T.: Conditional gene targeting for cancer gene therapy. Adv Drug Deliv Rev 2001, 53, 135- 154.
  • 6. Kaczmarczyk E., Małolepszy J., Bojarojć-Nosowicz B., Bongrac E.: Polymorphism of the α-lactalbumin gene and populations and subpopulations of peripheral blood lymphocytes in heifers naturally infected with bovine leukaemia virus. Bull Vet Inst Pulawy 2005, 49, 279- 286.
  • 7. Kamiński S.: Identification of the Sdu I site polymorphism within 5' flanking region of bovine alpha- lactalbumin gene. Anim Sci Pap Rep 1999, 17, 23-27.
  • 8. Kurek C: Immunological basis of resistance and immunity of udder in cows. Medycyna Wet 1988, 1, 27- 30.
  • 9. McKenzie H.A., White F.H.Jr.: Lysozyme and alpba- lactalbumin: structure, function, and interrelationships. Adv Protein Chem 1991, 41, 173-315.
  • 10. Osta R., Garcia-Muro E., Zarazaga I.: A Mspl polymorphism at the bovine α-lactalbumin gene. Anim Genetics 1995, 26, 104-105.
  • 11. Pawelski S.: Diagnostyka laboratoryjna w hematologii. PZWL, Warszawa 1983, pp. 481-485.
  • 12. Pinkiewicz E.: Podstawowe badania laboratoryjne w chorobach zwierząt. PWRiL, Warszawa 1990, pp. 123- 127.
  • 13. Raman U., Poland P.L.: A new micro-quantitative NBT- test. Pediatr Res 1975, 9, 334.
  • 14. Seyfert H-M.: Lactoferrin and lysozyme - two mammalian antibiotics. Arch Anim Breed 1999, 42, 22- 27.
  • 15. Stankiewicz W.: Hematologia weterynaryjna. PWRiL, Warszawa 1973, pp. 165-214.
  • 16. Ślopek S.: Immunologia praktyczna. PZWL, Warszawa 1970, pp. 181-189.
  • 17. Svensson M., Hakansson A., Mosseberg A.K., Linse S., Svanborg C.: Conversion of α-lactalbumin to a protein inducing apoptosis. Proc Natl Acad Sci USA 2000, 97, 4221-4226.
  • 18. Svensson M., Fast J., Mosseberg A.K., Düringer C., Gustafsson L., Hallgren O., Brooks C.L., Berliner L., Linse S., Svanborg C.: α-Lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human α-lactalbumin made lethal to tumors cells). Protein Sci 2003, 12, 2794-2804.
  • 19. Vilotte J.L., Soulier S., Printz C., Mercir J.C.: Sequence of the goat α-lactalbumin-encoding gene: comparison with the bovine gene and evidence of related sequences in the goat genome. Gene 1991, 98, 271-276.
  • 20. Voelkner G.R., Bleck G.T., Wheeler M.B.: Single-base polymorphism within 5' flanking region of the bovine alpha-lactalbumin gene. J Dairy Sci 1997, 80, 194-197.
  • 21. Walawski K., Pareek C.S., Czarnik U., Zabolewicz T.: High lysozyme activity families in Polish Black-and- White cattle. Acta Theriologica 1999, 44, 91-100.
  • 22. Winnicka A.: Wartości referencyjne podstawowych badań laboratoryjnych w weterynarii. Wydawnictwo SGGW, Warszawa 1997, pp. 51-52.

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Bibliografia

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