Antinociceptive effect of MAS MT in rats

• Autorzy: Rykaczewska-Czerwinska M. , Radosz A. , Szymanowska-Dziubasik K. , Konopinska D. , Plech A.
• Języki publikacji: EN

Abstrakty

EN

MAS MT is a myotropic decapeptide isolated from Manduca sexta. This peptide exerts stimulatory effect on insects heart-beat frequency. The present study was undertaken in order to determine a probable antinociceptive effect in rats of native synthetic decapeptide, MAS MT-I and its two analogs, heptapeptides MAS MT-II and MAS MT-III. All these peptides were applied directly into the lateral brain ventricle (icv) at three doses: 10, 25 and 50 nmol. The analgesic (antinociceptive) effect was evaluated by a tail immersion test. It was found that two doses of MAS MT-I: 25 and 50 nmol induced significant antinociceptive effect, while MAS MT-II and MAS MT-III exert a less antinociceptive effect in comparison with native MAS MT-I. Prior icv administration of naloxone, an opioid antagonist weakly blocked MAS MT-I effect. We conclude that antinociceptive effect of MAS MT-I in rats is not mediated by central opioid system.

Słowa kluczowe

EN

Tenebrio molitor; antinociceptive effect; rat; larva; brain; neuropeptide; insect neuropeptide; Manduca sexta; proctolin; myotropin; biological activity; peptide chain; peptide

• Wydawca: -
• Czasopismo: Pestycydy
• Rocznik: 2008
• Numer: 3-4
• Opis fizyczny: p.139-146,fig.,ref.

Twórcy

autor

Rykaczewska-Czerwinska M.

• Medical University of Silesia in Katowice, 28 Jordana St., 41-808 Zabrze, Poland

autor

Radosz A.

autor

Szymanowska-Dziubasik K.

autor

Konopinska D.

autor

Plech A.

Bibliografia

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