Influence of long-term zearalenone intoxication on the concentration of progesterone and 17beta-oestradiol in blood plasma in bitches

• Autorzy: Gajecka M , Janowski T. , Jakimiuk E. , Zielonka L. , Podhalicz-Dziegielewska M. , Obremski K. , Gajecki M.
• Języki publikacji: EN

Abstrakty

EN

The experiment was carried out on nine sexually mature, aged 1-3 years, clinically healthy bitches being in anoestrus. The animals were divided into two experimental groups and one control group. The bitches from the experimental groups were receiving zearalenone per os at the doses of 25 µg/kg b.w. and 50 µg/kg b.w., respectively for 100 d. The concentrations of zearalenone, progesterone, and 17β- oestradiol were analysed in weekly intervals. Zearalenone was noted as early as minute 30 and then during the whole experiment. High concentration of zearalenone (9.34 - 124.33 ng/mL.) was observed in weeks 6-9. The intoxication was accompanied by hormonal disturbances due to progesterone concentration (to 25-30 ng/mL) depending on zearalenone dose and by the increasing in 17β-oestradiol concentration (to 33 pg/ml). Hormonal disturbances of this kind are similar to those noted in different pathological conditions in the genital tract in bitches.

Słowa kluczowe

EN

zearalenone; experimental group; intoxication; 17beta-estradiol; animal; control group; blood plasma; progesterone concentration; bitch

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2008
• Tom: 52
• Numer: 3
• Opis fizyczny: p.405-409,fig.,ref.

Twórcy

autor

Gajecka M

• University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland

autor

Janowski T.

autor

Jakimiuk E.

autor

Zielonka L.

autor

Podhalicz-Dziegielewska M.

autor

Obremski K.

autor

Gajecki M.

Bibliografia

• 1. De Bosschere H., Ducatelle R., Tshamala, M., Coryn M.: Changes in sex hormone receptors during administration of progesterone to prevent estrus in the bitch. Theriogenology 2002, 58, 1209-1217.
• 2. De Bosschere H., Ducatelle R., Vermeirsch H., Simoens P., Coryn M.: Estrogen-α and progesterone receptor expression in cystic endometrial hyperplasia and pyometra in the bitch. Animal Reprod Sci 2002, 70, 251- 259.
• 3. Gajęcka M., Jakimiuk E., Polak M., Otrocka-Domagała I., Janowski T., Zwierzchowski W., Obremski K., Zielonka Ł., Apoznański J., Gajęcki M.: Zearalenone applied per os provides adverse effects in structure of chosen parts of bitch reproductive system. Polish J Vet Sci 2004, 7, 59-66.
• 4. Gajęcka M., Janowski T., Jakimiuk E., Polak M., Podhalicz-Dzięgielewska M., Rotkiewicz T., Otrocka- Domagała I., Obremski K., Zielonka Ł., Gajęcki M.: Histopathological and immunohistochemical examination of the uterus in bitches following zearalenon mycotoxicosis. Polish J Vet Sci 2007, 10, 143-151.
• 5. Galabova-Kovačs G., Walter I., Aurich C., Aurich J.E.: Steroid receptors in canine endometrial cells can be regulated by estrogen and progesterone under in vitro conditions. Theriogenology 2004, 61, 963-976.
• 6. Gobello C., de la Sota R.L., Goya R.G.: Study of the change of prolactin and progesterone during dopaminergic agonist treatments in pseudopregnant bitches. Animal Reprod Sci 2001, 66, 257-267.
• 7. Hoffmann B., Riesenbeck A., Klein R.: Reproductive endocrinology of bitches. Animal Reprod Sci 1996, 42, 275-288.
• 8. Miller K.P., Borgeest C., Greenfeld C., Tomic D., Flaws J.A.: In utero effects of chemicals on reproductive tissues in females. Toxicol Applied Pharmacol 2004, 198, 111-131.
• 9. Queiroga F.L., Pérez-Alenza M.D., Silvan G., Peña L., Lopes C., Illera J.C.:Role of steroid hormones and prolactin in canine mammary cancer. J Steroid Biochem Mol Biol 2005, 94, 181-187.
• 10. Smith D., Combes R., Depelchin O., Jacobsen S.D., Hack R., Luft J., Lammens L., von Landenberg F., Phillips B., Pfister R., Rabemampianina Y., Sparrow S., Stark C., Stephan-Gueldner M.: Optimizing the design of preliminary studies for pharmaceutical safety testing in the dog. Regul Toxicol Pharmacol 2005, 41, 95-101.
• 11. Tsumagari S., Ishinazaka T., Kamata H., Ohba S., Tanaka S., Ishii M., Memon M.A.: Induction of canine pyometra by inoculation of Escherichia coli into uterus and its relationship to reproductive features. Animal Reprod Sci 2005, 87, 301-308.
• 12. Van Cruchten S., Van den Broeck W., D'haeseleer M., Simoens P.: Proliferation patterns in the canine endometrium during the estrous cycle. Theriogenology 2004, 62, 631-641.
• 13. Ververidis H.N., Boscos C.M., Stefanakis A., Saratsis P., Stamou A.I., Krambovitis E.: Serum estradiol- 17β, progesterone and respective uterine cytosol receptor concentrations in bitches with spontaneous pyometra. Theriogenology 2004, 62, 614-623.
• 14. Zwierzchowski W., Gajęcki M., Obremski K., Zielonka Ł., Baranowski M.: The occurrence of zearalenone and its derivatives in standard and therapeutic feeds for companion animals. Polish J Vet Sci 2004, 7, 289-293.