Evaluation of medetomidine-midazolam-atropine (MeMiA) anesthesia maintained with propofol infusion in New Zealand White rabbits

• Autorzy: Rozanska D.
• Języki publikacji: EN

Abstrakty

EN

An anesthetic combination of medetomidine-midazolam-atropine and propofol was investigated in twenty New Zealand White rabbits. Each rabbit received combined medetomidine at a dosage of 0.2 mg/kg (b.w.), midazolam (0.5 mg/kg b.w.) and atropine (0.5 mg/kg b.w.) intramuscularly for induction of anesthesia. Propofol was administered intravenously - given to effect, and after that by an infusion pump to maintain anesthesia. The influence of the anesthetic combination on the cardiopulmonary system was evaluated by monitoring respiratory and heart rates, blood pressure, and arterial blood gas tensions. The results obtained showed that propofol infusion at a rate of 0.5 mg/kg b.w./min maintained general anesthesia effectively with few side effects on the cardiopulmonary system during 30 minutes. However, slight hypotension, hypercapnia, and respiratory acidosis were associated with infusion of this anesthetic. The recovery of the rabbits from the anesthesia was smooth. Two rabbits died 20 to 24 hours after anesthesia. In conclusion, an anesthetic combination with medetomidine-midazolam-atropine and propofol at the investigated doses was shown to be a safe method to induce and maintain general anesthesia enabling short-term surgical procedures in healthy animals.

Słowa kluczowe

EN

rabbit; New Zealand White rabbit; anaesthesia zob.anesthesia; anesthesia; propofol; medetomidine; midazolam; infusion; atropine; anesthetic combination; general anesthesia

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2009
• Tom: 12
• Numer: 2
• Opis fizyczny: p.209-216,fig.,ref.

Twórcy

autor

Rozanska D.

• University of Life Sciences in Lublin, Gleboka 30, 20-612 Lublin, Poland

Bibliografia

• Aeschbacher G, Webb AI (1993) Propofol in rabbits. 2. Long-term anesthesia. Lab Anim Sci 43: 328-335.
• Alibhai HIK, Clarke KW, Lee YH, Thompson J (1996) Car­diopulmonary effects of combinations of medetomidine hydrochloride and atropine sulphate in dogs. Vet Rec 138: 11-13.
• Ben-Shlomo I, Finger J, Bar-av E, Perl AZ, Etchin A, Tver- skoy M (1993) Propofol and fentanyl act addictively for induction of anaesthesia. Anaesthesia 48: 111-113.
• Bettschart-Wolfensberger R, Bowen MI, Freeman SL, Feller R, Bettschart RW, Nolan A, Clarke KW (2001) Car­diopulmonary effects of prolonged anesthesia via propofol-medetomidine infusion in ponies. Am J Vet Res 62: 1428-1435.
• Crankshaw DP (1988) Intravenous anesthetic agents. Med J Aust 149: 432-438.
• De Mulder PA, Van Kerckhoven RJ, Adriaensen HF, Gil- lebert TC, De Hert SG (1997) Continuous total intra­venous anesthesia, using propofol and fentanyl in an open-thorax rabbit model: evaluation of cardiac contrac­tile function and biochemical assessment. Lab Anim Sci 47: 367-375.
• Flecknell PA (1996) Laboratory animal anaesthesia: A prac­tical introduction for research workers and technicians, 2nd ed., Academic Press, London.
• Flecknell PA (1993) Anesthesia of animals for biomedical research. Br J Anaesth 71:885-894.
• Goodman NW, Black AMS, Carter JA (1987) Some ventila­tory effects of propofol as a sole anaesthetic agent. Br J Anaesth 59: 1497-1503.
• Grimm KA, Thurmon JC, Olson WA, Tranquilli WJ, Benson GJ (1998) The pharmacodynamics of thiopental, medetomidine, butorphanol and atropine in beagle dogs. J Vet Pharmacol Ther 21: 133-137.
• Gupta A, Lennmarken C, Vegfors M, Tyden H (1990) An­aesthesia for cardioversion. A comparison between propofol, thiopentone and midazolam. Anaesthesia 45: 872-875.
• Hall LW, Chambers JP (1987) A clinical trial of propofol infusion anaesthesia in dogs. J Small Anim Pract 28: 623-637.
• Hayashi K, Nishimura R, Yamaki A, Kim HY, Matsunaga S, Sasaki N, Takeuchi A (1994) Comparision of sedative effects induced by medetomidine, medetomidine- -midazolam and medetomidine-butorphanol in dogs. J Vet Med Sci 56: 951-956.
• Hellebrekers LJ, De Boer EJ, van Zuylen MA, Vosmeer H (1997) A comparison between medetomidine- -ketamine and medetomidine-propofol anaesthesia in rabbits. Lab Anim 31: 58-69.
• Hobbs BA, Rolhall TG, Sprenkel TL, Anthony KL (1991) Comparision of several combinations for anesthesia in rabbits. Am J Vet Res 55: 669-674.
• Hudson RJ (1992) Basic principles of clinical pharmacology, 1st ed., JB Lippincott Co, Philadelphia.
• Keegan RD, Greene SA (1993) Cardiovascular effects of a continuous two-hour propofol infusion in dogs. Com­parison with isoflurane anesthesia. Vet Surg 22: 537-543.
• Ko JC, Thurmon JC, Tranquilli WJ, Benson GJ, Olson WA (1992) A comparison of medetomidine-propofol and medetomidine-midazolam-propofol anesthesia in rabbits. Lab Anim Sci 42: 503-507.
• Kojima K, Nishimura R, Mutoh T, Hong S, Mochizuki M, Sasaki N (2002) Effects of medetomidine-midazolam, acepromazine-butorphanol, and midazolam-butorphanol on induction dose of thiopental and propofol and on car­diopulmonary changes in dogs. Am J Vet Res 63: 1671-1679.
• Komar E (1998) Znieczulanie zwierząt domowych i labora­toryjnych. 1st ed., Edward Komar Publishing, Lublin.
• Korner PI, Lfther JB, White SW (1968) Circulatory effects of chloralose-urethane and sodium pentobarbitone an­aesthesia in the rabbit. J Physiol 199: 253-265.
• Luo Y, Russell GB, Griffith JW, Lang CM (1995) Compari­son of anesthesia induced by ketamine-fentanyl combina­tion and maintained by propofol or etomidate in New Zealand White rabbits. Lab Anim Sci 45: 269-275.
• Ma D, Chakrabarti MK, Whitwam JG (1999) Propofol, bradycardia and the Bezold-Jarisch reflex in rabbits. Br J Anaesth 82: 412-417.
• Nilsson A, Persson MP, Hartvig P (1988) Effect of total intravenous anesthesia with midazolam-alfentanil on the adrenocortical and hyperglycemic response to abdominal surgery. Acta Anaesthesiol Scand 32: 379-382.
• Nishimura R, Kim H, Matsunaga S, Hayashi K, Tamura H, Sasaki N, Takeuchi A (1993) Sedative effect induced by a combination of medetomidine and midazolam in pigs. J Vet Med Sci 55: 717-722.
• Paddleford RR (2004) Znieczulenie ogólne u małych zwierząt, 1st ed., SIMA WLW, Warszawa.
• Peeters ME, Gil D, Teske E (1988) Four methods for gen­eral anesthesia in the rabbit: a comparative study. Lab Anim 22: 355-360.
• Perez-Martinez A, Gonzalvez-Pinera J, Marco-Macian A, Carpintero-Moreno F, Moya-Marchante M (1995) Propofol in continuous perfusion as anesthetic in experi­mental surgery in the rabbit. Rev Esp Anestesiol Reanim 42: 253-256.
• Raekallio M, Tulamo RM, Valtamo T (1998) Medetomidine-midazolam sedation in sheep. Acta Vet Scand 39: 127-134.
• Redondo JI, Gomez-Villamandos RJ, Santisteban JM, Dominguez JM, Ruiz I, Avila I (1999) Romifidine, medetomidine or xylazine before propofol-halothane-N20 anesthesia in dogs. Can J Vet Res 63: 31-36.
• Robertson SA, Johnston S, Beemsterboer J (1992) Cardipul- monary, anesthetic, and postanesthetic effects of intra­venous infusions of propofol in Greyhounds and non-Greyhounds. Am J Vet Res 53: 1027-1032.
• Różańska D, Różański P, Brodzki A (2007) The influence of manipulative stress on cardiopulmonary changes in New Zealand White rabbits. J Pre-Clinical Clin Res 1: 189-192.
• Sano T, Nishimura R, Mochizuki M, Sasaki N (2003) Effects of midazolam-butorphanol, acepromazine-butor- phanol and medetomidine on an induction dose of propofol and their compatibility in dogs. J Vet Med Sci 65: 1141-1143.
• Sebel PS, Lowdon JD (1989) Propofol: a new intravenous anesthetic. Anesthesiology 71: 260-277.
• Svensson TH, Bunney BS, Aghajanian G (1975) Inhibition of both noradrenergic and serotoninergic neurons in the brain by the a-adrenergic agonist clonidine. Brain Res 92: 291-306.
• Thurmon JC, Ko JCH, Benson GJ, Tranquilli WJ, Olson WA (1994) Hemodynamic and analgesic effects of propofol infusion in medetomidine-premedicated dogs. Am J Vet Res 55: 363-367.
• Vainio O, Palmu L (1989) Cardiovascular and respiratory effects of medetomidine in dogs and influence of an­ticholinergics. Acta Vet Scand 30: 401-408.
• Vainio O (1989) Introduction to the clinical pharmacology of medetomidine. Acta Vet Scand 85: 85-88.
• Wyatt JD, Scott RA, Richardson ME (1989) The effects of prolonged ketamine-xylazine intravenous infusion on ar­terial blood pH, blood gases, mean arterial blood press­ure, heart and respiratory rates, rectal temperature and reflexes in the rabbit. Lab Anim Sci 39: 411-416.