Decreases in urine specific gravity and urinary creatinine in dogs with different diseases but with normal renal function

• Autorzy: Fojut-Palka B. , Winnicka A.
• Języki publikacji: EN

Abstrakty

EN

The subject of this study was to determine urine specific gravity (USg) and urinary creatinine (UCrn) in dogs with different diseases but with normal renal function. Sick dogs with different diseases were divided into nine groups. Dogs suffering from polyuria/polydipsia, vomits, diarrhoea and females in oestrus or pregnant were excluded from the studies. The healthy dogs served as a control group. Over a three-year period, a total of 267 dogs were examined clinically as well as using imaging and laboratory diagnostics methods. In sick dogs, USg and UCrn were found to be essentially decreased (except animals with neurological and uterine diseases, and neurological diseases, respectively), as compared with normal dogs. In clinically healthy animals of the control group, UCrn and USg did not significantly differ between the females and males. As for the control group, no correlation between UCrn/USg and the body weight/age was found, either.

Słowa kluczowe

EN

animal disease; dog; urine specific gravity; urinary creatinine; renal function; normal renal function; creatinine

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2008
• Tom: 11
• Numer: 1
• Opis fizyczny: p.41-46,ref.

Twórcy

autor

Fojut-Palka B.

• Small Animal Practice, Bartnicza 3, Warsaw, Poland

autor

Winnicka A.

Bibliografia

• Barr DB, Wilder LC, Caudill SP, Gonzales AJ, Needham LL, Pirkle JL (2005) Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements. Environ Health Perspectives 113: 192-200.
• Barsanti JA, Finco DR (1979) Protein concentration in urine of normal dogs. Am J Vet Res 40: 1583-1588.
• Boroujerdi M, Mattocks AM (1983) Metabolism of cre­atinine in vivo. Clin Chem 29: 1363-1366.
• Brault JJ, Terjung RL (2003) Creatine uptake and creatine transporter expression among rat skeletal muscle fiber types. Am J Physiol Cell Physiol 284: C1481-C1489.
• Braun JP, Lefebvre HP, Watson ADJ (2003) Creatinine in the dog: A Review. Vet Clin Path 32: 162-179.
• Carrieri M, Trevisan A, Bartolucci GB (2001) Adjustment to concentration-dilution of spot urine samples: correlation between specific gravity and creatinine. Int Arch Occup Environ Health 74: 63-67.
• Chanoit GP, Concordet D, Lefebvre HP, Orcel K, Braun JP (2002) Exercise does not induce major changes in plasma muscle enzymes, creatinine, glucose and total proteins concentrations in untrained Beagle Dogs. J Vet Med 49: 222-224.
• de Scally MP, Lobetti RG, Reyers F, Humphris D (2004) Are urea and creatinine values reliable indicators of azotaemia in canine babesiosis? J S Air Vet Assoc 75: 121-124.
• Dossin O, Germain C, Braun JP (2003) Comparison of the techniques of evaluation of urine dilution/concentration in the dog. J Vet Med A 50: 322-325.
• Feeman WE, Couto CG, Gray TL (2003) Serum creatinine concentrations in retired racing Greyhounds. Vet Clin Path 32: 40-42.
• Forrester SD, Martinez NI, Panciera DL, Moon ML, Pickett CR, Ward DL (2003) Absence of urinary tract infection in dogs with experimentally induced hyperadrenocorti- cism. Res Vet Sci 74: 179-182.
• Haddow JE, Knight GJ, Palomaki GE, Neveux LM, Chil- monczyk BA (1994) Replacing creatinine measurements with specific gravity values to adjust urine cotinine con­centrations. Clin Chem 40: 562-564.
• Fleiene R, Moe L, Mplmen G (2001) Calculation of urinary enzyme excretion, with renal structure and function in dogs with pyometra. Res Vet Sci 70: 129-137.
• Ikeuchi J, Yoshizaki T, Hirata M (1991) Plasma biochemis­try values of young beagle dogs. J Toxic Sci 16: 49-59.
• Izzat NN, Rosborough JP (1989) Renal function in con­scious dogs: potential effect of gender on measurement. Res Exp Med 189: 371-379.
• Jones JD, Burnett PC (1974) Creatinine metabolism in hu­mans with decreased renal function: creatinine deficit. Clin Chem 20: 1204-1212.
• Lowe JA, Murphy M, Nash V (1998) Changes in plasma and muscle creatine concentration after increases in supple­mentary dietary creatine in dogs. J Nutr 128 (Suppl 12): 2691S-2693S.
• Mansfield CS, Jones BR, Spillman T (2003) Assessing the severity of canine pancreatitis. Res Vet Scien 74: 137-144.
• Médaille C, Trumel C, Concordet D, Vergez F, Braun JP (2004) Comparison of plasma/serum urea and creatinine concentrations in the dog: a 5-year retrospective study in a Commercial Veterinary Clinical Pathology L aboratory. J Vet Med A 51: 119-123.
• Miller RC, Brindle E, Holman DJ, Shofer J, Klein NA, Soules MR, O’Connor KA (2004) Comparison of specific gravity and creatinine for normalizing urinary reproduc­tive hormone concentrations. Clin Chem 50: 924-932.
• Moriguchi J, Ezaki T, Tsukahara T, Fukui Y, Ukai H, Okamoto S, Shimbo S, Sakurai H, Ikeda M (2005) De­creases in urine specific gravity and urinary creatinine in elderly women. Int Arch Occup Environ Health 78: 438-445.
• Mundim AV, Coelho AO, Hortêncio SM, Guimarâes EC, Espindola FS (2007) Influence of age and sex on the serum biochemical profile of Doberman dogs in the growth phase. Comp Clin Path 16: 41-46.
• Narayanan S, Appleton HD (1980) Creatinine: A Review. Clin Chem 26: 1119-1126.
• Neel JA, Grindem CB (2000) Understanding and evaluating renal function. Vet Med 95: 555-565.
• Newman DJ, Pugia MJ, Lott JA, Wallace JF, Hiar AM (2000) Urinary protein and albumin excretion corrected by creatinine and specific gravity. Clin Chim Acta 294 (1-2): 139-155.
• Nyssa JR, Langston CE (2005) Urinalysis interpretation: How to squeeze out the maximum information from a small sample. Clin Tech Small Anim Pract 20: 2-10.
• Palacio J, Liste F, Gascon M (1997) Enzymuria as an index of renal damage in canine leishmaniasis. Vet Rec 140: 477-480.
• Rose RJ, Bloomberg MS (1989) Responses to sprint exer­cise in the greyhound: effects on haematology, serum bio­chemistry and muscle metabolites. Res Vet Sci 47: 212-218.
• Schàfer-Somi S, Bàr-Schadler S, Aurich JE (2005) Pro­teinuria and immunoglobulinuria in neonatal dogs. Vet Rec. 157: 378-382.
• Snow DH, Harris RC, Stuttard E (1988) Changes in haema­tology and plasma biochemistry during maximal exercise in greyhounds. Vet Rec 123: 487-489.
• Swanson KS, Kuzmuk KN, Schook LB, Fahey GC (2004) Diet affects nutrient digestibility, hematology, and serum chemistry of senior and weanling dogs. J Anim Sci 82: 1713-1724.
• Sykut-Cegielska J, Gradowska W, Mercimek-Mahmutoglu S, Stôckler-Ipsiroglu S (2004) Biochemical and clinical characteristics of creatine deficiency syndromes. Acta Biochim Pol 51: 875-882.
• Uechi M, Terui H, Nakayama T, Mishina M, Wakao Y, Takahashi M (1994) Circadian variation of urinary en­zymes in the dog. J Vet Med Sci 56: 849-854.
• van Vonderen IK, Koistra HS, Rijnberg A (1997) Intra- and interindividual variation in urine osmolality and urine specific gravity in healthy pet dogs of various ages. J Vet Int Med 11: 30-35.
• Watson AD, Church DB, Fairburn AJ (1981) Postprandial changes in plasma urea and creatinine concentrations in dogs. Am J Vet Res 42: 1878-1880.
• Watson ADJ, Lefebvre HP, Concordet D, Laroute V, Ferré JP, Braun JP, Conchou F, Toutain PL (2002) Plasma exogenous creatinine clearance test in dogs: comparison with other methods and proposed limited sampling strat­egy. J Vet Intern Med 16: 22-33.
• Winnicka A. (2004) Wartości referencyjne podstawowych badań laboratoryjnych w weterynarii. Wyd. SGGW, War­szawa.
• Wolford ST, Schroer RA, Gohs FX, Gallo PP, Falk HB, Dente AR (1988) Effect of age on serum chemistry pro­file, electrophoresis and thyroid hormones in beagle dogs two weeks to one year of age. Vet Clin Pathol 17: 35-42.
• Wyss M, Kaddurah-Daouk R (2000) Creatine and creatinine metabolism. Physiol Rev 80: 1107-1213.