Development and validation of a liquid chromatography method for the determination of nitrofurans in water

• Autorzy: Pietruszka K , Olejnik M. , Sell B.
• Języki publikacji: EN

Abstrakty

EN

A liquid chromatographic method coupled with UV- Vis and photodiode-array detection for the determination of nitrofuran residues: nitrofurazone, nitrofurantoin, furazolidone, and furaltadone in water was developed and validated. Confirmation of the identity of nitrofurans was performed by liquid chromatography-mass spectrometry with atmospheric pressure chemical ionization interface. The nitrofurans were isolated from water by solid-phase extraction and complete separation was obtained using a C18 analytical column and the mobile phase consisting of acetonitrile and 0.01 M sodium acetate buffer pH=6.0 (250:750, v/v), with the detection at λ=376 nm. Average recoveries for the compounds ranged from 63% to 90%. The results of the validation show that the method can be successfully used for the official control of nitrofurans in water.

Słowa kluczowe

EN

furazolidone; determination; nitrofuran; validation; nitrofurantoin; development; liquid chromatography method; food analysis; furaltadone; water; nitrofurazone

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2007
• Tom: 51
• Numer: 2
• Opis fizyczny: p.267-270,fig.,ref.

Twórcy

autor

Pietruszka K

• National Veterinary Research Institute, 24-100 Pulawy, Poland

autor

Olejnik M.

autor

Sell B.

Bibliografia

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