Progress in development of vaccines against most important gastrointestinal helminth parasites of humans and animals

• Autorzy: Wedrychowicz H , Wisniewski M
• Języki publikacji: EN

Abstrakty

EN

Among many vaccine approaches developed against gastrointestinal helminths in the recent years, parenteral vaccination and use of recombinant helminth antigens expressed in various expression systems have been a major focus. Significant progress has been made towards cloning of protective worm antigens. The recombinant proteins have several benefits over classic vaccine technologies, including increased safety, economy, stability and versatility. Moreover, the identification of site and developmental stage of the parasite in which the expression of genes encoding for potential vaccine antigen become possible using a variety of molecular techniques including hybridization in situ, expressed sequence tags analysis or cDNA microarray technology. Unfortunately, in the research reported so far little attention has been paid to oral vaccination, which may be of particular importance for the development of protective immunity against enteric parasites. The biggest obstacles to vaccine production at present time are: lack of an efficient expression system, which could guarantee proper post-translational modifications of recombinant helminth antigens as well as lack of efficient mucosal delivery systems. These obstacles will be possibly successfully overcome by use of transgenic plants both for the antigen expression and as adjuvants.

Słowa kluczowe

EN

parasite; DNA vaccine; vaccination; vaccine; hybridization; oral vaccine; recombinant antigen; gene encoding; gastrointestinal helminth; helminth

• Wydawca: -
• Czasopismo: Acta Parasitologica
• Rocznik: 2003
• Tom: 48
• Numer: 4
• Opis fizyczny: p.239-245,ref.

Twórcy

autor

Wedrychowicz H

• Department of Molecular Biology, W. Stefański Institute of Parasitology, Polish Academy of Sciences, 51-55 Twarda Street, 00-818 Warsaw, Poland
• Department of Parasitology, Faculty of Veterinary Medicine, Warsaw Agriculture University, 8 Ciszewskiego Street, 02-786 Warszawa, Poland

autor

Wisniewski M

• Department of Parasitology, Faculty of Veterinary Medicine, Warsaw Agriculture University, 8 Ciszewskiego Street, 02-786 Warszawa, Poland

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