Damage to erythrocytes caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin [in vitro]

• Autorzy: Bukowska B
• Języki publikacji: EN

Abstrakty

EN

The effects of the exposure of human erythrocytes to different concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin were studied. Particular attention was paid to lipid peroxidation, haemoglobin oxidation, and changes in the activity of catalase and glutathione peroxidase. Human erythrocytes at a 5% haematocrit were incubated with 2,3,7,8-TCDD at concentrations of 0.2 ppm to 1.6 ppm (ng-mg/ml erythrocytes) for 1 hour. The results obtained show that 2,3,7,8-TCDD induces the generation of lipid peroxides and the oxidation of Hb, and decreases the activity of catalase and glutathione peroxidase. This supports the thesis that TCDD causes oxidative stress in erythrocytes.

Słowa kluczowe

EN

hemoglobin oxidation; 2,3,7,8-tetrachlorodibenzo-p-dioxin; erythrocyte; catalase; glutathione peroxidase; lipid peroxidation

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2004
• Tom: 09
• Numer: 2
• Opis fizyczny: p.261-270,fig.,ref.

Twórcy

autor

Bukowska B

• University of Lodz, Banacha 12-16, 90-237 Lodz, Poland

Bibliografia

• 1. Płaza, G. Dioxin - dangerous compounds. Ochr. Poz. 28 (1994) 39-42, in Polish.
• 2. Ahlborg, U.G., Lipworth, L., Ernstoff, L.T., Hsieh, C.C., Hanberg, A., Baron, J., Trichopoulos, D. and Adami, H.O. Organochloride Compounds in relation to breast cancer, endometrial cancer, and endometriosis: An assessment of the biological and epidemiological evidence. Crit. Rev. Toxicol. 25 (1995) 463-531.
• 3. Moos, A.B. and Kerkvliet, N.I. Inhibition of tumor necrosis factor activity fails to restore 2,3,7,8-tetrachlorodiebenzo-p-dioxin (TCDD)-induced suppression of the antibody response to sheep red blood cells. Toxicol. Lett. 81 (1995) 175-181.
• 4. Fan, F., Wierda, D. and Rozman, K.K. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on humoral and cell-mediated immunity in Sprague-Dawley rats. Toxicology 106 (1996) 221-228.
• 5. Kimata, H. 2,3,7,7-tetrachlorodibenzo-p-dioxin selectively enhances spontaneous IgE production in B cells from atopic patients. Int. J. Hyg. Environ. Health 206 (2003) 601-604.
• 6. Alsharif, N.Z., Grandjean, C.J., Murray, W.J. and Stohs, S.J. TCDD -induced decrease in the fluidity of rat liver membranes. Xenobiotica 20 (1990) 979-988.
• 7. Kogevinas, M., Becher, H., Benn, T., Bertazzi, P.A., Boffetta, P., Bueno-de-Mesquita, H.B., Coggon, D., Colin, D., Flesch-Janys D., Fingerhut, M., Green, L., Kauppinen, T., Littorin, M., Lynge, E., Mathews, J.D., Neuberger, M., Pearce, N. and Saracci, R. Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols and dioxins. Am. J. Epidemiol. 145 (1997) 1061-1075.
• 8. Sewall, C.H., Lucier, G.W., Tritscher, A.M. and Clark, G.C. TCDD-mediated changes in hepatic epidermal growth factor receptor may be a critical event in the hepatocarcinogenic action of TCDD. Carcinogenesis 14 (1993)1885-1893.
• 9. Cole, P., Trichopoulos D., Pastides H., Starr T. and Mandel J.S. Dioxin and cancer: a critical review. Regul. Toxicol. Pharmacol. 38 (2003) 378-388.
• 10. Huuskonen, H., Unkila, M., Pohjanvirta, R. and Tuomisto, J. Developmental toxicity of TCDD in the most TCDD-resistant and susceptible rat strains. Toxicol. Appl. Pharmacol. 124 (1994) 174-180.
• 11. Pohjanvirta, R. and Tuomisto, J. Remarkable residual alterations in responses to feeding regulatory challenges in Ham/Wistar rats after recovery from the acute toxicity of TCDD. Food Chem. Toxicol. 28 (1990) 677-686.
• 12. Park, J.H., Hahn, E.J., Kong, J.H., Cho, H.J., Yoon, C.S., Cheong, S.W., Oh, G.S. and Youn, H.J. TCDD-induced apoptosis in EL-4 cells deficient of the aryl hydrocarbon receptor and down-regulation of IGFBP-6 prevented the apoptotic cell death. Toxicol. Lett. 145 (2003) 55-68.
• 13. Staples, J.E., Murante, F.G., Fiore, N.C. and Gasiewicz, T.A. and Silverstone, A.E. Tymic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are strictly dependent on aryl hydrocarbon receptor activation in hemopoietic cells, J. Immunol. 160 (1998) 3844-3854.
• 14. Huang, P., Ceccatelli, S., Hoegberg, P., Shi T.J.S., Hakansson H. and Rannug A. TCDD-induced expression of AH receptor responsive genes in the pituitary and brain of cellular retinol-binding protein (CRBP-I) knockout mice. Toxicol. Appl. Pharmacol. 192 (2003) 262-274.
• 15. Pohjanvirta, R. and Tuomisto, J. Short-term toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals: Effects, mechanisms and animal models. Pharm. Reviews (1994) 483-532.
• 16. Laskowska-Klita, T. and Chelchowska, M. Antioxidant status in erythrocytes of cystic fibrosis children. Acta Biochim. Pol. 48 (2001) 283285.
• 17. Sakamoto, M.K, Mima, S., Takahashi, K.P. and Tanimura, T. Apoptotic cell death of erythrocytes in Xenopus larvae exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Pathol. 25 (1997) 398-402.
• 18. Schecter, A., McGee, H., Stanley, J.S. Boggess, K. and Brandt-Rauf, P. Dioxins and dioxin-like chemicals in blood and semen of American Vietnam veterans from the state of Michigan. Am. J. Indust. Med. 30 (1996) 647654.
• 19. Coenraads, P.J., Olie K. and Tang, N.J. Blood lipid concentrations of dioxins and dibenzofurans causing chloracne. Br. J. Dermatol. 141 (1999) 694-697.
• 20. Nowak, E., Wyrwicz, G., Dąbrowski, Z., Smoleński, O. and Spodarek, K. Rheological and biochemical examination of red blood cells after treatment with different pharmacological and toxic substances. Clin. Hemorheol. Microcirc. 26 (2002) 91-97.
• 21. Stock, J. and Dormandy, T.L. The oxidation of human red cell lipids induced hydrogen peroxide. Brit. J. Haemat. 20 (1971) 95-111.
• 22. Dodge, I.T., Mitchell, C. and Hanahan, D.J. The preparation and chemical characteristics of haemoglobin-free ghost of human erythrocytes. Arch. Biochim. Biophys. 100 (1963) 119-130.
• 23. Drabkin, D.I. Spectrophotometric studies. XIV the crystalographic and optical properties of the haemoglobin of man in comparison with those of other species. J. Biol. Chem. 164 (1946) 703-723.
• 24. Rice-Evans, C.A., Diplock, A.T. and Symons, M.C.R. Techniques in Free Radical Resarch, Elsevier, Amsterdam (1991).
• 25. Aebi, H. Catalase in vitro. Methods Enzymol. 105 (1984) 121-126.
• 26. Duchnowicz, P. and Koter, M. Damage to the erythrocyte membrane cased by chlorophenoxyacetic herbicides. Cell. Mol. Biol. Lett. 8 (2003) 25-30.
• 27. Bukowska, B., Chajdys, A., Duda, W. and Duchnowicz, P. Effect of phenoxyherbicides and their metabolites on the activity of catalase in the human erythrocyte. Cell Biol. Int. 24 (2000) 705-711.
• 28. Morikofer-Zwez, S., Cantz, M., Kaufmann, H. and Aebi, H. Heterogeneity of erythrocyte catalase. Eur. J. Biochem. 11 (1969) 49-57.
• 29. Aebi, H., Wyss, S.R., Scherz, B. and Skvaril, F. Heterogeneity of erythrocyte catalase II. Isolation and characterization of normal and variant erythrocyte catalase and their subunits. Eur. J. Biochem. 48 (1974) 137145.
• 30. Hassoun, E.A., AlGhafri, M. and Abushaban, A. The role of antioxidant enzymes in TCDD-induced oxidative stress in various brain regions of rats after subchronic exposure. Free Radic. Biol. Med. 35 (2003) 1028-1036.
• 31. Bartosz, G. The other face of oxygen. PWN Warszawa (1995) pp. 125-187, in Polish.
• 32. Hilscherova, K., Blankenship, A.L., Nie, M., Coady, K.K., Upham, B.L., Trosko J.E. and Giesy J.P. Oxidative stress in liver and brain of the hatchling chicken (Fallus domesticus) following in ovo injection with TCDD. Com. Biochem. Physiol. C - Toxicol. Pharmacol. 136 (2003) 2945.