Brain-gut and appetite regulating hormones in the control of gastric secretion and mucosal protection

• Autorzy: Konturek S.J. , Brzozowski T. , Konturek P.C. , Schubert M.L. , Pawlik W.W. , Padol S. , Bayner J.
• Języki publikacji: EN

Abstrakty

EN

The progress in basic and clinical gastrology indicates that gastric mucosal integrity represents a balance between offensive and defensive factors. The main offensive factors appear to be gastric acid and pepsin under health conditions, while the non-steroidal anti-inflammatory drugs (NSAID) and Helicobacter pylori (H. pylori), infecting this mucosa, are currently considered the most important “aggressive” factors under pathological conditions. To the list of the aggressive factors, also stress, certain cytokines (TNF-, IL-8, IL-11 and IL-18) and oxygen or nitrogen free radicals should be added. The aims of this review is the presentation of the involvement of aggressive and protective factors in the control of gastric acid secretion and appetite regulating hormones in maintaining gastric mucosal integrity and its protection against damaging factors.

Słowa kluczowe

EN

vagus nerve; interleukin 18; interleukin 11; gastric secretion; infection; tumour necrosis factor-alpha; gastric acid; Helicobacter pylori; nonsteroidal antiinflammatory drug; interleukin 8; melatonin; gastroprotection; gastric acid secretion; gastrin; leptin; ghrelin; mucosal damage

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology. Supplement
• Rocznik: 2008
• Tom: 59
• Numer: 2
• Opis fizyczny: p.7-31,fig.,ref.

Twórcy

autor

Konturek S.J.

• Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Krakow, Poland

autor

Brzozowski T.

autor

Konturek P.C.

autor

Schubert M.L.

autor

Pawlik W.W.

autor

Padol S.

autor

Bayner J.