A possible involvement of plasma membrane NAD[P]H oxidase in the switch mechanism of the cell death mode from apoptosis to necrosis in menadione-induced cell injury

• Autorzy: Niemczyk E. , Majczak A. , Hallmann A. , Kedzior J. , Wozniak M. , Wakabayashi T.
• Języki publikacji: EN

Abstrakty

EN

The effects of inhibitors of plasma membrane NADPH oxidase on menadione-in­duced cell injury processes were studied using human osteosarcoma 143B cells. The intracellular level of superoxide in the cells treated with menadione for 6 h reached a maximum followed by an abrupt decrease. The population of apoptotic cells detected by Annexin V and propidium iodide double staining also reached its maximum at 6 h of menadione-treatment while that of necrotic cells increased continuously reaching 90% of the total population at 9 h of the treatment. Pretreatment of the cells with in­hibitors of NADPH oxidase, including diphenyliodonium chloride, apocynin, N-vani- llylnonanamide and staurosporine was effective in lowering the menadione-induced elevations of superoxide, and also in the suppression of the switch of the cell death mode from apoptosis to necrosis in menadione-treated cells except for the case of staurosporine. These results strongly suggest that superoxide generated by NADPH oxidase, besides that generated by the mitochondria, may contribute to the remark­able increase in the intracellular level of superoxide in the cells treated with menadione for 6 h resulting in the switch from apoptosis to necrosis, although a di­rect evidence of the presence of active and inactive forms of NADPH oxidase in con­trol and menadione-treated 143B cells is lacking at present.

Słowa kluczowe

EN

human osteosarcoma; superoxide; NADPH oxidase; plasma membrane; apocynin; menadione; necrosis; diphenyliodonium chloride; apoptosis; N-vanillylnonanamide; staurosporine; 143B cell

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2004
• Tom: 51
• Numer: 4
• Opis fizyczny: p.1015-1022,fig.,ref.

Twórcy

autor

Niemczyk E.

• Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland

autor

Majczak A.

autor

Hallmann A.

autor

Kedzior J.

autor

Wozniak M.

autor

Wakabayashi T.

Bibliografia

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