Emerging roles of proteasomes in ischemia-reperfusion injury of organs

• Autorzy: Kukan M.
• Języki publikacji: EN

Abstrakty

EN

Proteasomes are the main non-lysosomal, multicatalytic proteinase complexes involved in the degradation of most intracellular proteins and in numerous cell processes. Studies from isolated cell models indicate that agents that induce oxidative stress may also damage proteasomes. Similarly, continuous oxidative stress during cell aging may impair proteasome activity. In ischemia-reperfusion models of organ injury, proteasomes may be involved in several ways. First, proteasomes were found to be targets of ischemia-reperfusion injury of the brain and heart. Second, proteasome activity increased in liver models of ischemia-reperfusion. Third, proteasome inhibition prevented ischemia-reperfusion injury of the brain, heart and kidney. A major mechanism by which proteasome inhibititors may confer tissue protection is inactivation of transcription activator nuclear factor-B resulting in a block of expression of cytokines and cell adhesion molecules during the reperfusion phase. Thus, proteasome inhibition represents a novel strategy for the treatment of pathologies such as stroke, infarction, and kidney failure.

Słowa kluczowe

EN

brain; organ; oxidative stress; surgery; protein oxidation; kidney; heart; free radical; ischaemia-reperfusion injury; proteasome; transplantation

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2004
• Tom: 55
• Numer: 1,1
• Opis fizyczny: p.3-15,fig.,ref.

Twórcy

autor

Kukan M.

• Slovak Medical University, Limbova 12, 83303 Bratislava, Slovakia