The markers of oxidative stress and activity of the antioxidant system in the blood of elderly patients with essential arterial hypertension

• Autorzy: Kedziora-Kornatowska K , Cuczejko J. , Pawluk H. , Kornatowski T. , Motyl J. , Szadujkis-Szadurski L. , Szewczyk-Golec K. , Kedziora J.
• Języki publikacji: EN

Abstrakty

EN

We estimated the nitrate/nitrite, carbonyl groups, reduced glutathione (GSH) and malondialdehyde (MDA) concentrations and Cu,Zn superoxide dismutase (SOD-1), catalase (CAT), glutathione peroxidase (cGSH-Px) and glutathione S-transferase (GST) activities in the blood of 17 normotensive young subjects (mean age 39±7.0 years), 21 normotensive elderly subjects (mean age 82±8.2 years) and 38 patients with essential arterial hypertension (mean age 73±8.0 years). Our examinations showed that hypertension in the elderly is associated with greater than normal levels of protein and lipid oxidation, decreased nitric oxide concentration and an imbalance in antioxidant status (decreased GSH concentration and SOD-1 activity). The increased activity of GST compensated the decreased activity of cGSH-Px in the blood of hypertensive patients. Our study confirms that the degree of oxidative stress in elderly patients intensifies, especially if said patients have associated essential arterial hypertension.

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2004
• Tom: 09
• Numer: 4A
• Opis fizyczny: p.635-641,ref.

Twórcy

autor

Kedziora-Kornatowska K

• L. Rydygier Medical Academy of Bydgoszcz, Curie Sklodowskiej 9, 85-094 Bydgoszcz, Poland

autor

Cuczejko J.

autor

Pawluk H.

autor

Kornatowski T.

autor

Motyl J.

autor

Szadujkis-Szadurski L.

autor

Szewczyk-Golec K.

autor

Kedziora J.

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