Wirus pryszczycy i jego budowa molekularna

• Autorzy: Paprocka G

Warianty tytułu

EN

Foot-and-mouth disease virus and its molecular structure

• Języki publikacji: PL

Abstrakty

EN

Foot-and-mouth disease virus (FMDV) is an important animal pathogen that belongs to the Aphthovirus genus of the Picornaviridae family and infects cattle and other cloven-hoofed animals. Seven serotypes (A, O, C, Asia1, SAT1, SAT2 and SAT3) have been identified serologically, and multiple subtypes occur within each serotype. FMDV enters cells by receptor-mediated endocytosis. By electron microscopy the FMD virion appears to be a round particle with a smooth surface and a diameter of about 25 nm. The FMD viral particle contains a positive-strand RNA genome of about 8500 nucleotides, enclosed within a protein capsid. The virus capsid is made up from 60 copies each of four virus-encoded proteins VP1 to VP4. The FMDV genome is composed of the 5’ non-translated region (5’NTR), the coding region, and the 3’ non-translated region (3’NTR). The genome encodes a single polyprotein, from which the different viral polypeptides are derived by viral proteases. FMDV populations are genetically and anti-genetically heterogeneous. FMDV have very high mutation rates.

Słowa kluczowe

PL

budowa molekularna; genom wirusa; wirusologia; zmiennosc antygenowa; wirus pryszczycy

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2006
• Tom: 62
• Numer: 07
• Opis fizyczny: s.753-756,rys.,tab.,bibliogr.

Twórcy

autor

Paprocka G

• Panstwowy Instytut Weterynaryjny - Panstwowy Instytut Badawczy w Pulawach, ul.Wodna 7, 98-220 Zdunska Wola

Bibliografia

• 1.Baranowski E., Ruiz-Jarabo C. M., Sevilla N., Andreu D., Beck E., Domingo E.: Cell recognition foot-and-mouth disease virus that lacks the RGD integrin-binding motif: flexibility in aphthovirus receptor usage. J. Virol. 2000, 74, 1641-1647.
• 2.Barton D. J., O'Donnell B. J., Flanegan J. B.: 5' cloverleaf in poliovirus RNA is a cis-acting replication element required for negative-strand synthesis. EMBO J. 2001, 20, 1439-1448.
• 3.Belsham G. J.: Distinctive features of foot-and-mouth disease virus, a member of the picornavirus family; aspects of virus protein synthesis, protein processing and structure. Progress in Biophysics and Molecular Biology 1993, 60, 241-260.
• 4.Borrego B., Camarero J. A., Mateu M. G., Domingo E.: A highly divergent antigenic site of foo-and-mouth disease virus retains its immunodominance. Viral Immunol. 1995, 8, 11-18.
• 5.Cao X. M., Bergmann I. E., Beck E.: Comparison of the 5' and 3' untranslated genomic regions of virulent and attenuated foot-and-mouth disease viruses (strains O1 Campos and C3 Resende). J. Gen. Virol. 1991, 72, 2821-2825.
• 6.Capozzo A. V. E., Burke D. J., Fox J. W., Bergmann I. E., La Tore J. L., Grigera P. R.: Expression of foot-and-mouth disease virus non-structural polypeptide 3 ABC induces histone H3 cleavage in BHK21 cells. Virus Res. 2002, 90, 91-99.
• 7.Clavijo A., Wright P., Kitching P.: Developments in diagnostic techniques for differentiating infection from vaccination in foot-and-mouth disease. Vet. J. 2004, 1, 9-22.
• 8.Devaney M. A., Vakharia V. N., Lloyd R. E., Ehrenfeld E., Grubman M. J.: Leader protein of foot-and-mouth disease virus is required for cleavage of the p220 component of the cap binding protein complex. J. Virol. 1988, 62, 4407-4409.
• 9. Domingo E., Diez J., Martinez M. A., Hernandez J., Holguin A., Borego B., Mateu M. G.: New observations on antigenic diversification of RNA viruses. J. Gen. Virol. 1993, 74, 2039-2045.
• 10.Domingo E., Escarmis C., Baranowski E., Ruiz-Jarabo C. M., Carrillo E., Nunez J. I., Sobrino F.: Evolution of foot-and-mouth disease virus. Virus Res. 2003, 91, 47-63.
• 11.Drake J. W., Holland J. J.: Mutation rates among RNA viruses. Proc. Natl. Acad. Sci. 1999, 96, 13910-13913.
• 12.Duque H., Baxt B.: Foot-and-mouth disease virus receptors:comparison of bovine alpha(V) integrin utilization by type A and O viruses. J. Virol. 2003, 77, 2500-2511.
• 13.Duque H., LaRocco M., Golde W. T., Baxt B.: Intractions of foot-and-mouth disease virus with soluble bovine αᵥ β₃ and αᵥ β₆ integrins. J. Virol. 2004, 78, 9773-9781.
• 14.Escarmis C., Toja M., Medina M., Domingo E.: Modifications of the 5'untranslated region of foot-and-mouth disease virus after prolonged persistence in cell culture. Virus Res. 1992, 26, 113-125.
• 15.Fares M. A., Moya A., Escarmis C., Baranowski E., Domingo E., Barrio E.: Evidence for positive selection in the capsid protein-coding region of the foot-and-mouth disease virus (FMDV) subjected to experimental passage regimens. Mol. Biol. Evol. 2001, 18, 10-21.
• 16.Forss S., Strebel K., Beck E., Schaller H.: Nucleotide sequence and genome organization of foot-and-mouth disease virus. Nucleid Acids Res. 1984, 12, 6587-6601.
• 17.Haydon D. T., Bastos A. D., Knowles N. J., Samuel A. R.: Evidence for positive selection in foot-and-mouth disease virus capsid genes from field isolates. Genetics 2001, 157, 7-15.
• 18.Haydon D. T., Samuel A. R., Knowles N. J.: The generation and persistence of genetic variation in foot-and-mouth disease virus. Prev. Vet. Med. 2001, 51, 111-124.
• 19.Herold J., Andino R.: Poliovirus RNA replication requires genome circularization through a protein-protein bridge. Mol. Cell 2001, 7, 581-591.
• 20.Hinton T. M., Ross-Smith N., Warner S., Belsham G. J., Crabb B. S.: Conservation of L and 3C proteinase activities across distantly related aphthoviruses. J. Gen. Virol. 2002, 83, 3111-3121.
• 21.Jackson T., Ellard F. M., Ghazaich R. A., Brookes S. M., Blakemore W. E., Corteyn A. H., Stuart D. I., Newman J. W., King A. M.: Efficient infection of cells in culture by type O foot-and-mouth disease virus requires binding to cell surface heparan sulfate. J. Virol. 1996, 70, 5282-5287.
• 22.Jackson T., Mould A. P., Sheppard D., King A. M.: Integrin αᵥ β₁ is receptor for foot-and-mouth disease virus. J. Virol. 2002, 76, 935-941.
• 23.Jackson T., King A. M., Stuart D. I., Fry E.: Structure and receptor binding. Virus Res. 2003, 91, 33-46.
• 24.Jackson T., Clark S., Berryman S., Burman A., Cambier S., Mu D., Nishimura S., King A. M. Q.: Integrin{alpha}v {beta}8 functions as a receptor for foot-and-mouth disease virus: role of the {beta}- chain cytodomain in integrin-mediated infection. J. Virol. 2004, 78, 4533-4540.
• 25.King A. M., McCahon D., Saunders K., Newma J. W., Slade W. R.: Multiple sites of recombination within the RNA genome of foot-and-mouth disease virus. Virus Res. 1985, 3, 373-384.
• 26.Kuhn R., Luz N., Beck E.: Functional analysis of the internal translation initiation site of foot-and-mouth disease virus. J. Virol. 1990, 64, 4625-4631.
• 27.Lopez de Quinto S., Saiz M., de la Morena D., Sobrino F., Martinez-Salaz E.: IRES-driven translation is stimulated separately by the FMDV 3'- NCR and poly(A) sequences. Nucleid Acids Res. 2002, 30, 4398-4405.
• 28.Mason P. W., Bezborodova S. V., Henry T. M.: Identification and characterization of a cis - acting replication (cre) adjacent to the internal ribosome entry site of foot-and-mouth disease virus. J. Virol. 2002, 76, 9686-9694.
• 29.Mayo M. A.: Virus taxonomy - Houston 2002. Arch. Virol. 2002, 147, 1071-1076.
• 30.Paprocka G., Kęsy A.: Zastosowanie hodowli komórek do namnażania wirusa pryszczycy. Biotechnologia 1992, 18, 15-20.
• 31.Paul A. V., Van Boom J. H., Filippov D., Wimmer E.: Protein-primed RNA synthesis by purified poliovirus RNA polymerase. Nature 1998, 393, 280-284.
• 32.Paul A. V.: Possible unifying mechanism of picornavirus genome replication, [w:] Semler B. L., Wimmer E. (red.): Molecular biology of picornaviruses, ASM Press, Washington 2002, s. 227-246.
• 33.Rohll J. B., Moon D. H., Evans D. J., Almond J. W.: The 3' untranslated region of picornavirus RNA: features required for efficient genome replication. J. Virol. 1995, 69, 7835-7844.
• 34.Röhrer H., Olechnowitz A. F.: Maul- und Klauenseuche. VEB Gustav Fischer Verlag, Jena 1980, s. 16.
• 35.Rueckert R. R.: Picornaviridae: the viruses and their replication, [w:] Fields B. N., Knipe D. M., Howley P. M. (red.): Fields virology, Lippincott-Raven Publishers, Philadelphia 1996, s. 609-654.
• 36.Ryan M. D., Flint M.: Virus-encoded proteinases of the picornavirus super group. J. Gen. Virol. 1997, 78, 699-723.
• 37.Ryan M. D., King A. M. Q., Thomas G. P. M.: Cleavage of foot-and-mouth disease virus polyprotein is mediated by residues located within a 19 amino acid sequence. J. Gen. Virol. 1991, 72, 2727-2732.
• 38.Saiz M., Gomez S., Martinez-Salas E., Sobrino F.: Deletion or substitution of the aphtovirus 3'NCR abrogates infectivity and viral replication. J. Gen. Virol. 2001, 82, 93-101.
• 39.Tosh C., Hemadri D., Sanyal A.: Evidence of recombination in the capsid-coding region of type A foot-and-mouth disease virus. J. Gen. Virol. 2002, 83, 2455-2460.
• 40.Van Rensburg H., Haydon D., Joubert F., Bastos A., Heath L., Nel L.: Genetic heterogeneity in the foot-and-mouth disease virus Leader and 3C proteinases. Gene 2002, 289, 19-29.