Molecular modelling of membrane activity of amphotericin B, a polyene macrolide antifungal antibiotic

• Autorzy: Baginski M. , Sternal K. , Czub J. , Borowski E.
• Języki publikacji: EN

Abstrakty

EN

Amphotericin B (AmB) is a well known polyene macrolide antibiotic used to treat systemic fungal infections. Despite its toxicity AmB is still regarded as a life-saving drug. The lack of adequate knowledge of the AmB mechanism of action is a serious obstacle to efficient development of new less toxic derivatives. Complementary to various experimental approaches, computational chemistry methods were used to study AmB mechanism of action. A programme lasting for a decade, that was run by our group covered studies of: i) molecular properties of AmB and its membrane targets, ii) structure and properties of AmB membrane channels, and iii) interaction of AmB with the membrane.

Słowa kluczowe

EN

polyene macrolide antibiotic; molecular modelling; ergosterol; lipid membrane; amphotericin B; antibiotic; cholesterol; antifungal antibiotic; membrane activity

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2005
• Tom: 52
• Numer: 3
• Opis fizyczny: p.655-658,fig.,ref.

Twórcy

autor

Baginski M.

• Gdansk University of Technology, Gdansk, Poland

autor

Sternal K.

autor

Czub J.

autor

Borowski E.

Bibliografia

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