Alpha-ketoglutarate dehydrogenase and lipoic acid synthase are important for the functioning of peroxisomes of Saccharomyces cerevisiae

• Autorzy: Smaczynska-de Rooij I , Migdalski A. , Rytka J.
• Języki publikacji: EN

Abstrakty

EN

A method was devised to search for yeast mutants impaired in peroxisome functioning, indicating cross-talk between metabolic pathways. Two mutants were isolated; they are impaired in oleate utilisation and carry mutations in the KGD1 and LIP5 genes encoding the E1 component of the mitochondrial α-ketoglutarate dehydrogenase complex and lipoic acid synthase, respectively. The results presented indicate that the Kgd1 and Lip5 proteins are important for the expression of genes encoding peroxisomal matrix proteins, although they are not necessary for the biogenesis of this cellular compartment.

Słowa kluczowe

EN

alpha-ketoglutarate dehydrogenase; yeast mutant; lipoic acid; mutant; peroxisome; Saccharomyces cerevisiae

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2004
• Tom: 09
• Numer: 2
• Opis fizyczny: p.271-286,fig.,ref.

Twórcy

autor

Smaczynska-de Rooij I

• Polish Academy of Sciences, Pawinskiego 5A, 02-106 Warsaw, Poland

autor

Migdalski A.

autor

Rytka J.

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