Metabolic interaction in rats treated with acetylsalicylic acid anbd trichloroethyline

• Autorzy: Zielinska-Psuja B. , Orlowski J. , Plewka A. , Kaminski M. , Kowalowka-Zawieja J. , Zieba-Proc B.
• Języki publikacji: EN

Abstrakty

EN

The influence of acetylsalicylic acid (ASA) on elimination of trichloroacetic acid and trichloroethanol in the urine and liver and kidney of cytochrome P-450-dependent monooxygenase systems in rats exposed to trichloroethylene (TRI) vapours were examined. The obtained results show that acetylsalicylic acid decreased the elimination of both trichloroethylene metabolites and induced cytochrome P-450 concentration in the liver, whereas slightly inhibited cytochrome b5 and activites of NADPH-cytochrome P-450 reductase and NADH-cytochrome b5 reductase. After mixed exposures, acetylsalicylic acid elevated cytochrome P-450 concentration and NADPH-cytochrome P-450 reductase activity to values observed in the control group. The concentration of cytochrome b5 was much lower than after ASA or trichloroethylene alone. The activity of NADPH-cytochrome P-450 reductase was strongly inhibited by TRI, whereas in ASA presence was elevated, but it was still lower than in control. Acetylsalicylic acid stimulates cytochrome P-450, however other compounds of MFO system do not react positively on this ester.

Słowa kluczowe

EN

trichloroacetic acid; trichloroethylene; treatment; trichloroethanol; dependent monooxygenase; cytochrome P450; metabolic interaction; rat; acetylsalicylic acid

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 1999
• Tom: 08
• Numer: 5
• Opis fizyczny: p.319-325,ref.

Twórcy

autor

Zielinska-Psuja B.

• Karol Marcinkowski University of Medical Sciences, Poznan, Poland

autor

Orlowski J.

autor

Plewka A.

autor

Kaminski M.

autor

Kowalowka-Zawieja J.

autor

Zieba-Proc B.

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