Osteocalcin and forearm bone mineral density in women

• Autorzy: Nowicka G , Debinski A , Wlodarczyk M , Wieniawska-Szewczyk E , Wajszczyk B

Warianty tytułu

PL

Osteokalcyna a gestosc mineralna kosci przedramienia u kobiet

• Języki publikacji: EN

Abstrakty

EN

Osteocalcin is synthesized by osteoblasts and incorporated into bone matrix. During bone resorption by osteoclasts, osteocalcin is released from bone matrix. Plasma osteocalcin level may be used as a bone turnover marker. The aim of the study was to assess a relationship between osteocalcin level in blood and forearm bone mineral density in women. Significant negative correlation between osteocalcin concentration and bone mineral density of forearm mid distal region was found.

PL

Osteokalcyna jest syntetyzowana przez osteoblasty i wbudowywana do macierzy kostnej. Podczas resorpcji kości przez osteoklasty jest ona usuwana z macierzy kostnej. Poziom osteokalcyny w osoczu może być uznany za marker obrotu kostnego. Celem badań była ocena relacji między stężeniem osteokalcyny a gęstością mineralną kości przedramienia u kobiet. Zaobserwowano istnienie odwrotnej korelacji między stężeniem osteokalcyny a gęstością mineralną kości przedramienia w obszarze środkowo-dystalnym.

Słowa kluczowe

PL

woman; osteoporosis; human disease; bone mineral density; osteocalcin; bone matrix

• Wydawca: -
• Czasopismo: Żywienie Człowieka i Metabolizm
• Rocznik: 2008
• Tom: 35
• Numer: 4
• Opis fizyczny: p.283-288,fig.,ref.

Twórcy

autor

Nowicka G

• Department of Genomics and Genetic of Metabolic Diseases, National Food and Nutrition Institute, Warsaw, Poland

autor

Debinski A

• Department of Genomics and Genetic of Metabolic Diseases, National Food and Nutrition Institute, Warsaw, Poland

autor

Wlodarczyk M

• Department of Genomics and Genetic of Metabolic Diseases, National Food and Nutrition Institute, Warsaw, Poland

autor

Wieniawska-Szewczyk E

• Department of Biochemistry, II Medical Faculty, Warsaw Medical University, Warsaw

autor

Wajszczyk B

• Department of Epidemiology, National Food and Nutrition Institute, Warsaw

Bibliografia

• 1. Anonymous.: Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am. J. Med., 1993,94,646.
• 2. Palvanen M., Kannus P., Niemi S., et al.: Secular trends in the osteoporotic fractures in the distal hummerus in elderly women. Eur. J. Epidemiol., 1998, 14, 159.
• 3. Gullberg B., Johnell O., Kanis J.A.: World-wide projections for hip fracture. Osteoporos. Int., 1997, 7, 407.
• 4. Aerssens J., Dequeker J., Mbuyi-Muamba J.M.: Bone tissue composition: biochemical anatomy of bone. Clin. Rheumatol., 1994,13 (Suppl. 1), 54.
• 5. Nishimoto S.K., Price P.A.: Secretion of the vitamin K-dependent protein of bone by rat osteosarcoma cells. J. Biol. Chem., 1980, 255, 6579.
• 6. Delmas P.D.: Biochemical markers of bone turnover. J. Bone Miner. Res., 1993, 8 (Suppl. 2), S549.
• 7. Roger A., Hannon R.A., Eastell R.: Biochemical markers as predictors of rates bone loss after menopause. J. Bone Min. Res., 2000, 15, 1398.
• 8. Ivaska K.K., Hentunen T.A., Vaaaraniemi J., et al.: Release of intact and fragmented osteocalcin molecules from bone matrix during bone resorption in vitro. J. Biol. Chem., 2004,279, 18361.
• 9. Parfitt A.M.: The bone remodeling compartment: A circulatory function for bone lining cells. J. Bone Min. Res., 2001, 16, 1583.
• 10. Ravn P., Fledelius C., Rosenquist C., et al.: High bone turnover is associated with low bone mass in both pre- and postmenopausal women. Bone 1996,9,291.
• 11. Hitz M.F., Jensen J-E.B., Eskildsen P.C.: Bone mineral density and bone markers in patients with a recent low-energy fracture: effect of 1y of treatment with calcium and vitamin D. Am. J. Clin. Nutr., 2007, 86, 251.
• 12. Delmas P.D: Diagnostic procedures for osteoporosis in the elderly. Horm. Res., 1995, 43, 80. 13. Eriksen E.F., Axelrod D.W., Meisen F.: Bone histo- morphometry. New York, Raven Press, 1994.
• 14. Szulc P., Chapuy M-C., Meunier P.J., et al.: Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. J. Clin. Invest., 1993, 91, 1769.
• 15. Parviainen M.T., Pirskanen A., Mahonen A., et al.: Use of non-collagen markers in osteoporosis studies. Calc. Tissue Int., 1991,49 Suppl.: S26.
• 16. Watts N.B.: Clinical utility of biochemical markers of bone remodeling. Clin. Chem., 1999, 45, 1359.
• 17. Riggs B.L., Melton L.J. III.: Involutional osteoporosis. N. Eng. J. Med., 1986,314, 1676.
• 18. Ingle B.M., Hay S.M., Bottjer H.M., et al.: Changes in bone mass and bone turnover following distal forearm fracture. Osteoporos. Int., 1999, 10, 399.
• 19. Ingle B.M., Estell R.: Bone loss from hand in women following distal forearm fracture. Osteoporos. Int., 2001,12, 610.