Neurotoxic effect of copper salts in rats

• Autorzy: Plech A , Klimkiewicz T. , Jakrzewska H.
• Języki publikacji: EN

Abstrakty

EN

Neurotoxic effects of copper ions after intraperitoneal (ip) and intracerebroventricular (icv) injections of CuSO4 • 5H2O and Cu(CH,COO) 2 • H2O at doses of 1-100 nmols icv and 0.1-100 pmols/kg ip was deter­mined in rats using two behavioural methods: exploratory and locomotor activity in an open field test and spatial memory in a water maze test. It has been found that higher doses of copper salts (100 nmols icv and 100 ^mols/kg ip) significantly decreased spatial memory of rats.

Słowa kluczowe

EN

copper salt; copper ion; spatial memory; rat; neurotoxic effect

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 2000
• Tom: 09
• Numer: 4
• Opis fizyczny: p.301-304,fig.

Twórcy

autor

Plech A

• Medical University of Silesia, H.Jordan Str.38, 41-808 Zabrze, Poland

autor

Klimkiewicz T.

autor

Jakrzewska H.

Bibliografia

• 1. NORDBERG G.F.: Neurotoxic effect of metals and their compounds. Advances in Neurotoxicology ed. L. Manzo, N. Levy, Y. Lacasse, L. Roche, Pergamon Press, Oxford pp. 3-15, 1980.
• 2. DE VRIES D. J., SEWELL R. B., BEAST P. M.: Effect of copper on dopaminergic function in the rat corpus striatum. Exp. Neurol. 91, 546, 1986.
• 3. PROHASKA J. R.,BAILEY W. R.: Regional specificity in alternations of rat brain copper and catecholamines. J. Neurochem. 63, 1551, 1994.
• 4. BRUS R., MENGEL K., BARANIAK Z., RZES ZOTARSKA B., MASIUKIEWICZ E., KOWALSKA I, JAKRZEWSKA H., PLECH A.: Neurotoksyczne efekty miedziowego kompleksu gonadoliberyny (Cu-LH-RH) u szczurów. Konferencja naukowa jakość badan w to­ksykologii, Supraśl k. Biategostoku, 3-4 czerwca 1993, 37.
• 5. JANSSEN P.A.J., JAGENAU A.H.M, SCHELLEKENS K.H.L.: Chemistry and pharmacology of compounds related to 4-(4-hydroxy)-4-phenylpiperidino-butyrophenone. Part IV. Influence of haloperidol (R1025) and chlorpromazine on the behaviour of rat in unfamiliar open field' situation. Psychopharmacology 1, 389-392, 1960.
• 6. MORRIS R.: Development of a water maze procedure for studying spatial learning in the rat. J. Neurosci. Methods 11, 47, 1984.
• 7. SAITO T., NAGAO T., OKABE M., SAITO K.: Neurochemical and histochemical evidence for an abnormal catecholamines metabolism in the cerebral cortex of the Long-Evans Cinnamon rat before excessive copper accumulation in the brain. Neurosci. Lett. 216, 195, 1996.
• 8. DARWITA RR.: Changes in brain neurotransmitters in hypothalamus related to feeding behaviour in LEC rat. Hok- kaido-Igaku-Zasshi 71, 377, 1996.
• 9. PLECH A., RZESZOTARSKA B., KOWALSKA I.: Central effects of nickel complex LH-RH in rats, (unpublished data).