Cross-talk between the ATP and ADP nucleotide receptor signalling pathways in glioma C6 cells

• Autorzy: Czajkowski R. , Baranska J.
• Języki publikacji: EN

Abstrakty

EN

In this review we summarize the present status of our knowledge on the enzymes in­volved in the extracellular metabolism of nucleotides and the receptors involved in nucleotide signalling. We focus on the mechanism of the ATP and ADP signalling path­ways in glioma C6, representative of the type of nonexcitable cells. In these cells, ATP acts on the P2Y2 receptor coupled to phospholipase C, whereas ADP on two distinct P2Y receptors: P2Y1 and P2Y12. The former is linked to phospholipase C and the lat­ter is negatively coupled to adenylyl cyclase. The possible cross-talk between the ATP-, ADP- and adenosine-induced pathways, leading to simultaneous regulation of inositol 1,4,5-trisphosphate and cAMP mediated signalling, is discussed.

Słowa kluczowe

EN

cell membrane; phospholipase C; adenosine; glioma; signalling pathway; C6 cell; extracellular nucleotide; nucleotide receptor; adenylyl cyclase

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2002
• Tom: 49
• Numer: 4
• Opis fizyczny: p.877-889,fig.

Twórcy

autor

Czajkowski R.

• Nencki Institute of Experimental Biology, L.Pasteura 3, 02-093 Warsaw, Poland

autor

Baranska J.

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