Design, synthesis and biological evaluation of a new bridged immunosuppressor

• Autorzy: Szewczuk Z. , Wilczynski A. , Petry I. , Siemion I.Z. , Wieczorek Z.
• Języki publikacji: EN

Abstrakty

EN

A bridged peptide with the sequence: H-Thr-Pro-Gln-Arg-Gly-Asp-Val-y-Abu-Asn- Asp-Gln-Glu-Glu-Thr-Thr-Gly-Val-Val-Ser-Thr-Pro-Leu-Ile-Arg-Asn-Gly-OH was de­signed to mimic the discontinuous epitope of the HLA-DQ molecule that might interact with CD4. The bridged peptide revealed distinct suppressory effect in the humoral im­mune response. This result supports our suggestion that the 164-172 region of the HLA-DQ molecule may enhance its interactions with coreceptors, possibly with CD4.

Słowa kluczowe

EN

cell surface; human leucocyte antigen; interaction; immunosuppressor; chemical synthesis; histocompatibility antigen; molecule

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2001
• Tom: 48
• Numer: 4
• Opis fizyczny: p.1147-1150,fig.

Twórcy

autor

Szewczuk Z.

• University of Wroclaw, F.Joliot-Curie 14, 50-383 Wroclaw, Poland

autor

Wilczynski A.

autor

Petry I.

autor

Siemion I.Z.

autor

Wieczorek Z.

Bibliografia

• 1.Szewczuk, Z., Siemion, I.Z. & Wieczorek, Z. (1996) Mol. Immunol. 33, 903-908.
• 2.Szewczuk, Z., Wieczorek, Z., Stefanowicz, P., Wilczyński, A. & Siemion, I.Z. (1997) Arch. Immunol. Exp. Ther.(Warsz) 45, 335-341.
• 3.Szewczuk, Z., Stefanowicz, P., Wilczyński, A., Siemion, I.Z., Cierniewski, C.S., Kralisz, U. & Wieczorek, Z. (1996) Biopolymers 40, 571-583.
• 4.Szewczuk, Z., Wilczynski, A., Dyba, M., Petry, I, Siemion, I.Z. & Wieczorek, Z. (2000) Peptides 21, 1849-1858.
• 5.Szewczuk, Z., Buczek, P., Stefanowicz, P., Krajewski, K., Siemion, I.Z. & Wieczorek, Z. (2001) Acta Biochim. Polon. 48, 121-130.
• 6.Cammarota,G., Scheirle, A.T.B., Doran, D.M., Knorr, R., Bannwarth, W., Guardiola, J. & Sinigaglia, F. (1992) Nature 356, 799-801.
• 7.Zagury,J.F., Bernard, J., Achour, A., Astgen, A., Lachgar, A., Fall, L., Carelli, C., Issing, W., Mbika, J.P., Picard, O., Carlotti, M., Callebaut, I., Mornon, J.P., Burny, A., Feldman, M., Bizzini, B. & Zagury, D. (1993) Proc. Natl. Acad. Sei. U.S.A.. 90, 7573-7577.
• 8.Szewczuk, Z., Wilczynski, A., Stefanowicz, P., Fedorowicz, W., Siemion, I.Z. & Wieczorek, Z. (1999) Mol. Immunol. 36, 525-533.