Functional eicosanoid test and typing [FET] in acetylsalicylic acid intolerant patients with urticaria

• Autorzy: Velten F.W. , Bayerl C. , Baenkler H.-W. , Schaefer D.
• Języki publikacji: EN

Abstrakty

EN

One of the common side effects of acetylsalicylic acid (ASA) is the induction of pseudoallergic reactions that range from urticarial wheals to anaphylactic shock. At present there is no reliable detection method available for the diagnosis of ASA-hypersensitivity and its relation to clinical symptoms. The purpose of the present study was to evaluate the functional eicosanoid typing (FET) score taking into account several parameters of the equilibrium between prostaglandins (PG) and peptido-leukotriens (pLT). A total eicosanoid pattern score (TEP) ranging from 0.0 to 3.0, was defined that exhibited significant differences (p 0.001) between ASA-intolerant patients and healthy subjects. In addition to the differentiation of both groups at a TEP cut-off value of 1.0, the increasing TEP values correlated with an increasing severity of clinical symptoms in ASA-intolerant patients. We conclude that the FET has the potential for the safe and reliable detection of ASA-intolerance and, probably, other eicosanoid-related pseudoallergic reactions.

Słowa kluczowe

EN

functional eicosanoid test; acetylsalicylic acid intolerance; patient; anaphylactic shock; hypersensitivity; prostaglandin; pseudoallergic reaction; urticaria; cardiovascular disease; cyclooxygenase; cysteinyl leukotriene

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology. Supplement
• Rocznik: 2006
• Tom: 57
• Numer: 12
• Opis fizyczny: p.35-46,fig.,ref.

Twórcy

autor

Velten F.W.

• Ruprecht Karls University of Heidelberg, Theodor-Kutzer Ufer 1-3, 68167 Mannheim, Germany

autor

Bayerl C.

autor

Baenkler H.-W.

autor

Schaefer D.