Involvement of the histaminergic system in cytidine 5'-diphosphocholine-induced reversal of critical haemorrhagic hypotension in rats

• Autorzy: Jochem J. , Savci V. , Filiz N. , Rybus-Kalinowska B. , Fogel W.A. , Yalcin M.
• Języki publikacji: EN

Abstrakty

EN

Cytidine 5’-diphosphocholine (CDP-choline) is an endogenously synthesized mononucleotide which exerts a variety of physiological effects by altering central cholinergic transmission. Administered intracerebroventricularly (i.c.v.) or intravenously, it reverses haemorrhagic hypotension in rats, apparently by the activation of central cholinergic receptors. The study was undertaken to investigate the involvement of the central histaminergic system in CDP-choline-mediated reversal of haemorrhagic hypotension. Experiments were carried out in male ketamine/xylazine-anaesthetised Wistar rats subjected to haemorrhagic hypotension of 20-26 mmHg. CDP-choline (2 µmol; i.c.v.) administered at 5 min of critical hypotension produced a long-lasting pressor effect with increases in mean arterial pressure (MAP), heart rate (HR), and renal, hindquarters and mesenteric blood flows, resulting in a 100% survival at 2 h. The action was accompanied by approximately a 26% increase in extracellular histamine concentration at the posterior hypothalamus, as measured by microdialysis. Cardiovascular effects mediated by CDP-choline were almost completely blocked by pretreatment with H1 receptor antagonist chlorpheniramine (50 nmol; i.c.v.), but not with H2 receptor blocker ranitidine (25 nmol; icv) or H3/H4 receptor antagonist thioperamide (50 nmol; i.c.v.). In conclusion, the present results show that the central histaminergic system, through the activation of H1 histaminergic receptors, is involved in CDP-choline-induced resuscitating effect in haemorrhage-shocked rats.

Słowa kluczowe

EN

histaminergic system; cytidine 5'-diphosphocholine; hemorrhagic hypotension; rat; hemorrhagic shock; histamine; microdialysis; arterial pressure; heart rate

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2010
• Tom: 61
• Numer: 1
• Opis fizyczny: p.37-43,fig.,ref.

Twórcy

autor

Jochem J.

• Medical University of Silesia, 18 Piekarska Street, 41-902 Bytom, Poland

autor

Savci V.

autor

Filiz N.

autor

Rybus-Kalinowska B.

autor

Fogel W.A.

autor

Yalcin M.

Bibliografia

• Sved AF, Ito S, Sved JC. Brainstem mechanisms of hypertension: role of the rostral ventrolateral medulla. Curr Hypertens Rep 2003; 5: 262-268.
• Pires W, Wanner SP, La Guardia RB, et al. Intracerebroventricular physostigmine enhances blood pressure and heat loss in running rats. J Physiol Pharmacol 2007; 58: 3-17.
• Bazzani C, Bertolini A, Ricigliano GM, Cainazzo MM, Balugani A, Guarini S. The reversal of experimental hemorrhagic shock induced by nicotine and dimethylphenylpiperazinium is adrenal-dependent. Resuscitation 1996; 31: 145-150.
• Secades JJ, Lorenzo JL. Citicoline: pharmacological and clinical review, 2006 update. Methods Find Exp Clin Pharmacol 2006; 28(Suppl B): 1-56.
• dibhatla RM, Hatcher JF. Cytidine-5’-diphosphocholine (CDP-choline) in stroke and other CNS disorders. Neurochem Res 2005; 30: 15-23.
• Savci V, Goktalay G, Cansev M, Cavun S, Yilmaz MS, Ulus IH. Intravenously injected CDP-choline increases blood pressure and reverses hypotension in haemorrhagic shock: effect is mediated by central cholinergic activation. Eur J Pharmacol 2003; 468: 129-139.
• Savci V, Cavun S, Goktalay G, Ulus IH. Cardiovascular effects of intracerebroventricularly injected CDP-choline in normotensive and hypotensive animals: the involvement of cholinergic system. Naunyn-Schmiedeberg’s Arch Pharmacol 2002; 365: 388-398.
• Brown RE, Stevens DR, Haas HL. The physiology of brain histamine. Prog Neurobiol 2001; 63: 637-672.
• Fogel WA, Stasiak A, Lewinski A, Maksymowicz M, Jochem J. Satiety signalling histaminergic system system and brain-gut peptides in regulation of food intake in rats with portocaval anastomosis. J Physiol Pharmacol 2008; 59(Suppl 2): 135-144.
• Jochem J. Cardiovascular effects of histamine administered intracerebroventricularly in critical haemorrhagic hypotension in rats. J Physiol Pharmacol 2000; 51: 229-239.
• Jochem J. Endogenous central histamine-induced reversal of critical hemorrhagic hypotension in rats – studies with L-histidine. Shock 2003; 20: 332-337.
• Yalcin M, Savci V, Jochem J. Involvement of the cholinergic system in the central histamine-induced reversal of critical haemorrhagic hypotension in rats. J Physiol Pharmacol 2009; 60: 133-137.
• Jochem J, Fogel WA, Rybus-Kalinowska B, Yalcin M, Savci V. Involvement of the histaminergic system in cytidine 5’-diphosphocholine-induced reversal of critical haemorrhagic hypotension in rats. XXXVIII Ann Meeting Eur Histamine Research Soc, 7-10.05.2008., Stockholm, Sweden, Abstracts Book: 55.
• Santos NR, Huston JP, Brandao ML. Blockade of histamine H2 receptors of the periaqueductal gray and inferior colliculus induces fear-like behaviors. Pharmacol Biochem Behav 2003; 75: 25-33.
• Jochem J: Haematological, blood gas and acid-base effects of central histamine-induced reversal of critical haemorrhagic hypotension in rats. J Physiol Pharmacol 2001; 52: 447-458.
• Jochem J: Central histamine-induced reversal of haemorrhagic shock in rats a comparison with the pressor effect of peripheral adrenergic receptor stimulation. Inflamm Res 2003; 52(Suppl 1): S41-S42.
• Yilmaz MS, Yalcin M, Savci V. Cytidine 5’-diphosphocholine restores blood flow of superior mesenteric and renal arteries and prolongs survival time in haemorrhaged anaesthetized rats. Clin Exp Pharmacol Physiol 2006; 33: 415-420.
• Cavun S, Savci V, Ulus IH. Centrally injected CDP-choline increases plasma vasopressin levels by central cholinergic activation. Fundam Clin Pharmacol 2004; 18: 71-77.
• Cavun S, Savci V. CDP-choline increases plasma ACTH and potentiates the stimulated release of GH, TSH and LH: the cholinergic involvement. Fundam Clin Pharmacol 2004; 18: 513-523.
• Jochem J. Involvement of the sympathetic nervous system in the reversal of critical haemorrhagic hypotension by endogenous central histamine in rats. Naunyn-Schmiedeberg’s Arch Pharmacol 2004; 369: 418-427.
• Jochem J. Involvement of the renin-angiotensin system in central histamine-induced reversal of critical haemorrhagic hypotension in rats. J Physiol Pharmacol 2004; 55: 39-55.
• Jochem J. Involvement of arginine vasopressin in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats. Inflamm Res 2004; 53: 269-276.
• Jochem J. Involvement of proopiomelanocortin-derived peptides in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats. J Physiol Pharmacol 2004, 55: 57-71.
• Jochem J: Central histamine-induced reversal of critical haemorrhagic hypotension in rats - haemodynamic studies. J Physiol Pharmacol 2002; 53: 75-84.
• Cenni G, Blandina P, Mackie K, et al. Differential effect of cannabinoid agonists and endocannabinoids on histamine release from distinct regions of the rat brain. Eur J Neurosci 2006; 24: 1633-1644.
• Szczepanska-Sadowska E. Role of neuropeptides in central control of cardiovascular response to stress. J Physiol Pharmacol 2008; 59(Suppl 8): 61-89.
• Wsol A, Cudnoch-Jedrzejewska A, Szczepanska-Sadowska E, Kowalewski S, Puchalska L. Oxytocin in the cardiovascular response to stress. J Physiol Pharmacol 2008; 59(Suppl 8): 123-127.
• Philippu A, Hagen R, Hanesch U, Waldmann U. Changes in the arterial blood pressure increase the release of endogenous histamine in the hypothalamus of anaesthetized cats. Naunyn-Schmiedeberg’s Arch Pharmacol 1983; 323: 162-167.
• Uteshev VV, Knot HJ. Somatic Ca2+ dynamics in response to choline-mediated excitation in histaminergic tuberomammillary neurons. Neuroscience 2005; 134: 133-143.
• Jochem J, Rybczyk R, Irman-Florjanc T, Zwirska-Korczala K, Niwecka A. Central serotonin-induced pressor effect in rats is mediated in part via the histaminergic system. Inflamm Res 2008; 57(Suppl 1): S35-S36.
• Jochem J, Zak A, Rybczyk R, Irman-Florjanc T. Interactions between the serotonergic and histaminergic systems in the central cardiovascular regulation in haemorrhage-shocked rats: involvement of 5-HT1A receptors. Inflamm Res 2009; 58(Suppl 1): 38-40.
• Mlynarska MS. Interaction between the central histaminergic and the muscarinic cholinergic systems. Agents Actions 1994; 41: C82-C84.
• Bacciottini L, Passani MB, Giovannelli L, et al. Endogenous histamine in the medial septum-diagonal band complex increases the release of acetylcholine from the hippocampus: a dual-probe microdialysis study in the freely moving rat. Eur J Neurosci 2002; 15: 1669-1680.
• Anthonisen M, Knigge U, Kjaer A, Warberg J. Histamine and prostaglandin interaction in the central regulation of ACTH secretion. Neuroendocrinology 1997; 66: 68-74.
• Bugajski J, Gadek-Michalska A, Bugajski AJ. Involvement of prostaglandins in the nicotine-induced pituitary-adrenocortical response during social stress. J Physiol Pharmacol 2002; 53: 847-857.
• Gadek-Michalska A, Bugajski AJ, Bugajski J. Nitric oxide and prostaglandins in the clenbuterol-induced ACTH and corticosterone secretion. J Physiol Pharmacol 2008; 59: 163-175.
• Gadek-Michalska A, Bugajski AJ, Bugajski J. Prostaglandins and interleukin-1beta in the hypothalamic-pituitary-adrenal response to systemic phenylephrine under basal and stress conditions. J Physiol Pharmacol 2008; 59: 563-575.