Syntetyczne oligodeoksynukleotydy zawierajace niemetylowane dinukleotydy cytozyno-guaninowe jako immunostymulatory u drobiu

• Autorzy: Szczubelek P , Szeleszczuk P.

Warianty tytułu

EN

Synthetic oligodeoxynucleotides consisting of unmethylated cytosine-guanosine dinucleotides as immunostimulators for poultry

• Języki publikacji: PL

Abstrakty

EN

Fragments of bacterial and viral DNA are identified by the immune system of vertebrates which cause the activation of specific and non-specific mechanisms of immunological response. Similar immunostimulating effects can be achieved by using oligodeoxynucleotides (ODN) consisting of unmethylated cytosine-guanosine dinucleotides (CpG ODN). Numerous studies show the capability of their appliance in treating bacterial, viral and parasitic infections, as well as in the therapy of tumors and cancers and in specific immunoprophylactics of many kinds of animal (including bird) diseases. This fact creates the capability of using CpG ODN in large scale poultry production. The authors describe the influence of CpG ODN on immune system cells and the possibilities of the practical application of CpG ODN in therapy and immunoprophylaxis of poultry diseases.

Słowa kluczowe

PL

drob; immunostymulatory; oligodeoksynukleotydy; oligodeoksynukleotydy CpG; dzialanie immunostymulujace; receptory toll-podobne

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2009
• Tom: 65
• Numer: 12
• Opis fizyczny: s.823-826,bibliogr.

Twórcy

autor

Szczubelek P

• Szkola Glowna Gospodarstwa Wiejskiego, ul.Ciszewskiego 8, 02-786 Warszawa

autor

Szeleszczuk P.

Bibliografia

• 1. Chace J. H., Hooker N. A., Mildenstein K. L., Krieg A. M., Cowdery J. S.: Bacterial DNA-induced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12. Clin. Immunol. Immunopathol. 1997, 84, 185-193.
• 2. Chu R. S., Askew D., Noss E. H., Tobian A., Krieg A. M., Harding C. V.: CpG oligodeoxynucleotides down-regulate macrophage class II antigen processing. J. Immunol. 1999, 163, 1188-1194.
• 3. Dalloul R. A., Lillehoj H. S., Klinman D. M., Ding X., Min W., Heckert R. A., Lillehoj E. P.: In ovo administration of CpG oligonucleotides and the recombinant microneme protein MIC2 protetects against Eimeria infections. Vaccine 2005, 23, 3108-3113.
• 4. Dalloul R. A., Lillehoj H. S., Okamura M., Xie H., Min W., Ding X., Heckert R. A.: In vivo effects of CpG oligodeoxynucleotide on Eimeria infection in chickens. Avian Dis. 2004, 48, 83-90.
• 5. Genovese L. L., Lowry V. K., Genovese K. J., Kogut M. H.: Longevity of augmented phagocytic activity of heterophils in neonatal chickens following administration of Salmonella enteritidis-immune lymphokines to chickens Avian Pathol. 2000, 29, 117-122.
• 6. Gomis S., Babiuk L., Allan B., Willson P., Edwin W., Hecker R., Potter A.: Protection of chickens against a lethal challenge of Escherichia coli by a vaccine containing CpG Oligodeoxynucleotides as an adjuvant. Avian Dis. 2006, 51, 78-83.
• 7. Gomis S., Babiuk L., Allan B., Willson P., Waters E., Ambrose N., Hecker R., Potter A.: Protection of neonatal chicks against a lethal challenge of Escherichia coli using DNA containing cytosine-phosphodiester-guanine motifs. Avian Dis. 2004, 48, 813-822.
• 8. Gomis S., Babiuk L., Godson D. L., Allan B., Thrush T., Townsend H., Willson P., Waters E., Hecker R., Potter A.: Protection of chickens against Escherichia coli infections by DNA containing CpG motifs. Infect. Immun. 2003, 71, 857-863.
• 9. Halpern M. D., Kurlander R. J., Pisetsky D. S.: Bacterial DNA induces murine interferon-γ production by stimulation of interleukin-12 and tumor necrosis factor-γ. Cell. Immunol. 1996, 167, 72-78.
• 10. Hartmann G., Weiner G. J., Krieg A. M.: CpG DNA: a potent signal for growth, activation, and maturation of human dendritic cells. Proc. Natl. Acad. Sci. USA 1999, 96, 9305-9310.
• 11. He H., Genovese K. J., Swaggerty Ch. L., Nisbet D. J., Kogut M. H.: In vivo priming heterophil innate immune functions and increasing resistance to Salmonella enteritidis infection in neonatal chickens by immune stimulatory CpG oligodeoxynucleotides. Vet. Immunol. Immunopathol. 2007, 117, 275-283.
• 12. He H., Lowry V. K., Swaggerty C. L., Ferro P.J., Kogut M. H.: In vitro activation of chicken leukocytes and in vivo protection against Salmonella enteritidis organ invasion and peritoneal S. enteritidis infection-induced mortality in neonatal chickens by immunostimulatory CpG oligodeoxynucleotide. Immunol. Med. Microbiol. 2005, 43, 81-89.
• 13. Hemmi H., Takeuchi O., Kawai T., Kaisho T., Sato S., Sanjo H., Matsumoto M., Hoshino K., Wagner H., Takeda K., Akira S.: A Toll-like receptor recognizes bacterial DNA. Nature 2000, 408, 740-745.
• 14. Huang L., Krieg A. M., Eller N., Scott D. E.: Induction and regulation of Th1-inducing cytokines by bacterial DNA, lipopolysaccharide, and heat-inactivated bacteria. Infect. Immun. 1999, 67, 6257-6263.
• 15. Jenkins K. A., Lowenthal J. W., Kimpton W., Bean A. G. D.: The in vitro and in ovo responses of chickens to TLR9 subfamily ligands. Dev. Comp. Immunol. 2009, 33, 660-667.
• 16. Krieg A. M.: Immune effects and mechanisms of action of CpG motifs. Vaccine 2001, 19, 618-622.
• 17. Linghua Z., Xingshan T., Fengzhen Z.: Vaccination with Newcastle disease vaccine and CpG oligodeoxynucleotides induces specific immunity and protection against Newcastle disease virus in SPF chicken. Vet. Immunol. Immunopathol. 2007, 115, 216-222.
• 18. Lipford G. B., Bendigs S., Heeg K., Wagner H.: Poly-guanosine motifs costimulate antigen-reactive CD8 T cells while bacterial CpG-DNA affect T-cell activation via antigen-presenting cell-derived cytokines. Immunology 2000, 101, 46-52.
• 19. Lipford G. B., Heeg K., Wagner H.: Bacterial DNA as immune cell activator. Trends Microbiol. 1998, 6, 496-500.
• 20. MacKinnon K. M., He H., Swaggerty C. L., McReynolds J. L., Genovese K. J., Duke S. E., Nerren J. R., Kogut M. H.: In ovo treatment with CpG oligodeoxynucleotides decreases colonization of Salmonella enteriditis in broiler chickens Vet. Immunol. Immunopathol. 2009, 127, 371-375.
• 21. Mahmood M. S., Siddique M., Hussain I., Khan A., Mansoor M. K.: Protection capability of recombinant plasmid DNA vaccine containing VP2 gene of very virulent infectious bursal disease virus in chickens adjuvanted with CpG oligodeoxynucleotide. Vaccine 2006, 24, 4838-4846.
• 22. Mutwiri G., van Drunen Littel-van den Hurk S., Babiuk L. A.: Approaches to enhancing immune responses stimulated by CpG oligodeoxynucleotides. Adv. Drug Deliv. Rev. 2009, 61, 226-232.
• 23. Patel B. A., Gomis S., Dar A., Willson P. J., Babiuk L. A., Potterb A., Mutwiri G., Tikoo S. K.: Oligodeoxynucleotides containing CpG motifs (CpG-ODN) predominantly induce Th1-type immune response in neonatal chicks. Dev. Comp. Immunol. 2008, 32, 1041-1049.
• 24. Roh H. J., Sung H. W., Kwon H. M.: Effects of DDA, CpG-ODN, and plasmid-encoded chicken IFN-gamma on protective immunity by a DNA vaccine against IBDV in chickens. J. Vet. Sci. 2006, 7, 361-368.
• 25. Scheule R. K.: The role of CpG motifs in immunostimulation and gene therapy Adv. Drug Deliv. Rev. 2000, 44, 119-134.
• 26. Stacey K. J., Sester D. P., Sweet M. J., Hume D. A.: Macrophage activation by immunostimulatory DNA. Curr. Top. Microbiol. Immunol. 2000, 247, 41-58.
• 27. Tascon R. E., Ragno S., Lowrie D. B., Colston M. J.: Immunostimulatory bacterial DNA sequences activate dendritic cells and promote priming and differentiation of CD8+ T cells. Immunology 2000, 99, 1-7.
• 28. Temperley N. D., Berlin S., Paton I. R., Griffin D. K., Burt D. W.: Evolution of the chicken Toll-like receptor gene family: A story of gene gain and gene loss. BMC Genomics 2008, 9, 62-73.
• 29. Tokunaga T., Yamamoto H., Shimada S., Abe H., Fukuda T., Fujisawa Y., Furutani Y., Yano O., Kataoka T., Sudo T.: Antitumor activity of deoxyribonucleic acid fraction from mycobacterium bovis GCG. Isolation, physicochemical characterization, and antitumor activity. J. Natl. Cancer Inst. 1984, 72, 955-962.
• 30. Vleugels V., Ververken C., Goddeeris B. M.: Stimulatory effect of CpG sequences on humoral response in chickens. Poult. Sci. 2002, 81, 1317-1321.
• 31. Vollmer J., Krieg A. M.: Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists. Adv. Drug Deliv. Rev. 2008, 61, 195-204.
• 32. Wang X., Jiang P., Deen S., Wu J., Liu X., Xu J.: Efficacy of DNA vaccines against infectious bursal disease virus in chickens enhanced by coadministration with CpG oligodeoxynucleotide. Avian Dis. 2003, 47, 1305-1312.
• 33. Wang Y., Shan C., Ming S., Liu Y., Du Y., Jiang G.: Immunoadjuvant effects of bacterial genomic DNA and CpG oligodeoxynucleotides on avian influenza virus subtype H5N1 inactivated oil emulsion vaccine in chicken. Res. Vet. Sci. 2009, 86, 399-405.
• 34. Weeratna R., Brazolot Millan C. L., Krieg A. M., Davis H. L.: Reduction of antigen expression from DNA vaccines by coadministered oligodeoxynucleotides. Antisense Nucleic Acid Drug Dev. 1998, 8, 351-356.
• 35. Xie H., Raybourne R. B., Babu U. S., Lillehoj H. S., Heckert R. A.: CpG-induced immunomodulation and intracellular bacterial killing in a chicken macrophage cell line. Dev. Comp. Immunol. 2003, 27, 823-834.
• 36. Yi A. K., Chang M., Peckham D. W., Krieg A. M., Ashman R. F.: CpG Oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry. J. Immunol. 1998, 160, 5898-5906.
• 37. Yilmaz A., Shen S., Adelson D. L., Xavier S, Zhu J. J.: Identification and sequence analysis of chicken Toll-like receptors. Immunogenetics 2004, 56, 743-753.
• 38. Zhang L., Zhang M., Li J., Cao T., Tian X., Zhou F.: Enhancement of mucosal immune responses by intranasal co-delivery of Newcastle disease vaccine plus CpG oligonucleotide in SPF chickens in vivo. Res. Vet. Sci. 2008, 85, 495-502.