Tumor cell N-glycans in metastasis

• Autorzy: Laidler P. , Litynska A.
• Języki publikacji: EN

Abstrakty

EN

Metastasis accounts for most of deaths caused by cancer. The increasing body of evidence suggests that changes in N-glycosylation of tumor cell proteins such as increased branching, increased sialylation, polysialylation, decreased fucosylation, enhanced formation of Lewis X and sialyl Lewis X antigens are among important factors determining metastatic potential of tumor cell. Most of the adhesion proteins, e.g., integrins, members of immunoglobulin superfamily, and cadherins are heavily N-glycosylated. The other proteins involved in adhesion, like galectins and type-C selectins, recognize N-glycans as a part of their specific ligands. In this review we focus on recent reports concerning the contribution of N-glycosylation of tumor cell adhesion molecules and some selected membrane proteins in the tumor invasion and metastasis.

Słowa kluczowe

EN

selectin; N-glycan; tumour cell; cadherin; galectin; cellular protein; integrin; metastasis; cancer

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1997
• Tom: 44
• Numer: 2
• Opis fizyczny: p.343-357

Twórcy

autor

Laidler P.

• Jagiellonian University, M.Kopernika 7, 31-034 Cracow, Poland

autor

Litynska A.

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