Effect of curcumin on atherosclerosis in apoE-LDLR - double knockout mice

• Autorzy: Olszanecki R. , Jawien J. , Gajda M. , Mateuszuk L. , Gebska A. , Korabiowska M. , Chlopicki S. , Korbut R.
• Języki publikacji: EN

Abstrakty

EN

It is widely appreciated that inflammation and oxidant stress contribute to atherogenesis. Curcumin, a polyphenolic natural compound has been reported to possess anti-inflammatory and anti-oxidant actions. We hypothesized that curcumin could inhibit the development of atherosclerosis in the apoE/LDLR - double knockout mice fed with Western diet (21% fat, 0.15% cholesterol w/w, without cholic acid). Curcumin (purity 98%), premixed with diet, was given for 4 months at a dose of 0.3 mg/per day/per mouse. In this model curcumin inhibited atherogenesis, measured both by "en face" method (25,15±2,9% vs. 19,2±0,6%, p<0,05) and "cross-section" method (565867±39764 µm2 vs. 299201±20373 µm2, p<0,05). Importantly, curcumin influenced neither the concentrations of cholesterol and triglycerides in blood nor animal body weight. To our knowledge, this is the first report that shows the anti-atherogenic effect of low dose of curcumin in fine model of atherosclerosis: gene-targeted apoE/LDLR - double knockout mice.

Słowa kluczowe

EN

curcumin; antiinflammatory action; antioxidant action; mouse; mice; oxidative stress; inflammation; atherosclerosis

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2005
• Tom: 56
• Numer: 4
• Opis fizyczny: p.627-635, fig.,ref.

Twórcy

autor

Olszanecki R.

• Jagiellonian University School of Medicine, Grzegorzecka Str.16, 31-531 Krakow, Poland

autor

Jawien J.

autor

Gajda M.

autor

Mateuszuk L.

autor

Gebska A.

autor

Korabiowska M.

autor

Chlopicki S.

autor

Korbut R.