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2006 | 15 | 1 |

Tytuł artykułu

A note on biallelic expression of the IGF2 gene in the liver and brain of adults pigs

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The IGF2 gene is imprinted in most mammalian tissues. Considering the potential large impact of the IGF2 gene on breeding industry, further studies on IGF2 expression in various tissues and at different stages of animal’s development are required. Samples of blood, muscle, kidney, liver and brain were taken from 5.5-month-old pigs. Animals heterozygous for SWC9 marker were selected. RNA was isolated from the muscle, kidney, liver and brain and RT-PCR was performed. The results of the study showed that there is a relaxation of imprinting of the IGF2 gene in the liver and brain of adult pigs.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

15

Numer

1

Opis fizyczny

p.57-60,fig.,ref.

Twórcy

autor
  • National Research Institute of Animal Production, Krakowska 1, 32-083 Balice, Poland
autor
autor
autor

Bibliografia

  • Amarger V., Nguyen M., Van Laere A.S., Braunschweig M., Nezer C., Georges M., Andersson L., 2002. Comparative sequence analysis of the INS-IGF2-H19 gene cluster in pigs. Mamm. Genome 13, 388-398
  • Braunschweig M.H., Van Laere A.S., Buys N., Andersson L., Andersson G., 2004. IGF2 antisense transcript expression in porcine postnatal muscle is affected by a quantitative trait nucleotide in intron 3. Genomics 84, 1021-1029
  • De Chiara T.M., Robertson E.J., Esfratadis A., 1991. Parental imprinting of the mouse insulin-like growth factor II gene. Cell 64, 849-859
  • Dindot S.V., Hansen G., Romano J., Piedrahita J.A., 2003. Genomic imprinting of the bovine IGF2, GTL2 and Xist loci. Theriogenology 59, 417
  • Kalscheuer V.M., Mariman E.C., Schepens M.T., Rehder H., Ropers H.H., 1993. The insulin-like growth factor type-2 receptor gene is imprinted in the mouse but not in humans. Nat. Genet. 5, 74-78
  • McLaren R.J., Montgomery G.W., 1999. Genomic imprinting of the insulin-like growth factor 2 gene in sheep. Mamm. Genome 10, 588-591
  • Moore T., Constancia M., Zubair M., Bailleul B., Feil R., Sasaki H., Reik W., 1997. Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2. Proc. Nat. Acad. Sci. USA 94, 12509-12514
  • Nezer C., Moreau L., Brouwers B., Coppieters W., Detilleux J., Hanset R., Karim L., Kvasz A., Leroy P., Georges M., 1999. An imprinted QTL with major effect on muscle mass and fat deposition maps to the IGF2 locus in pigs. Nat. Genet. 21, 155-156
  • Ogawa Y., Lee J.T., 2002. Antisense regulation in X inactivation and autosomal imprinting. Cytogenet. Genome Res. 99, 59-65
  • Ohlsson R., Hedborg F., Holmgren L., Walsh C., Ekstrom T.J., 1994. Overlapping patterns of IGF2 and H19 expression during human development: biallelic IGF2 expression correlates with a lack of H19 expression. Development 120, 361-368
  • Pedone P.V., Cosma M.P., Ungaro P., Colantuoni V., Bruni C.B., Zarrilli R., Riccio A., 1994. Parental imprinting of rat insulin-like growth factor II gene promoters is coordinately regulated. Biol. Chem. 269, 23970-23975
  • Pham N.V., Nguyen M.T., Hu J.F., Vu T.H., Hoffman A.R., 1998. Dissociation of IGF2 and H19 imprinting in human brain. Brain Res. 810, 1-8
  • Van Laere S., Nguyen M., Braunschweig M., Nezer C., Collette C., Moreau L., Archibald A.L., Haley C.S., Buys N., Tally M., Andersson G., Georges M., Andersson L., 2003. A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig. Nature 425, 832-836

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-12e557e9-caee-4246-b52b-c10259f1a122
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