EN
In this article the pharmacokinetic quality of antibacterial agents in fish has been reviewed. Oxytetracy- cline, and quinolones have been two of the most frequently used antibacterial substances in treatment of fish diseases. The use of another group of drugs is limited because of their efficacy, physico-chemical properties and human safety. In contrast to mammalian and other species, the environmental impact affects the pharmacokinetic parameters of anti-infective agents in fish. The influence of water temperature and salinity on the correlation between medications and ectothermic organisms have been emphasised. Generally, lower bioavailabilities and longer elimination times in fish have been established in contrast to other food-producing animals.