Zachowawcze leczenie zespolu endometritis-pyometra u suk z zastosowaniem aglepristonu

• Autorzy: Domoslawska A , Janowski T.

Warianty tytułu

EN

Non-invasive treatment of endometritis-pyometra complex with aglepristone

• Języki publikacji: PL

Abstrakty

EN

The aim of the study was to evaluate the efficacy of aglepristone - a progesterone receptor blocker - in the treatment of endometritis-pyometra complex (EPC) in bitches. 12 bitches of pure and mixed breeds between 2 and 13 years of age with EPC were examined. All animals were treated according to the same pattern: aglepristone (Alizine, Virbac®) was administered at the dose of 0.33 ml/kg, s.c. on days 1, 2, 7, and 14. Additionally, the antibiotic amoxycyline (Clamoxyl, Pfizer®) was administered at the dose of 1 ml/10 kg, s.c. every 48 hours for 10 days. A complete puss mass elimination, uterus involution and improvement of clinical state were observed after 3 weeks of treatment. Progesterone concentration, that was highly increased at the beginning of treatment, decreased to low levels during its first week. The leukocyte count (WBC), alkaline phosphatase (AP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) exceeded normal values before and in the first days of treatment. These parameters improved to normal values after the first week of treatment. The recurrence of EPC was not observed in any bitch during the next 2 years. Three bitches were mated in next heats but did not get pregnant. In the present study the antigestagens therapy proved highly effective: clinical recovery and the recurrence of normal haematological and biochemical counts were observed.

Słowa kluczowe

PL

psy; suki; choroby zwierzat; zespol endometritis-pyometra; leczenie zachowawcze; aglepriston; zastosowanie; skutecznosc

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2008
• Tom: 64
• Numer: 09
• Opis fizyczny: s.1146-1149,rys.,bibliogr.

Twórcy

autor

Domoslawska A

• Uniwersytet Warminsko-Mazurski w Olsztynie, ul.Oczapowskiego 14, 10-957 Olsztyn

autor

Janowski T.

Bibliografia

• 1.Arthur G. H., Noakes D. E., Pearson H., Parkinson T. J.: Veterinary Reproduction and Obstetrics. Saunders W. B. Comp., London 1996.
• 2.Baan M., Taverne M. A. M., Kooistra H. S., de Gier J., Dieleman S. J., Okkens A. C.: Induction of parturition in the bitch with the progesterone receptor blocker - aglepristone. Theriogenology 2005, 63, 1958-1972.
• 3.Birger M., Samborski Z.: Aktualne poglądy na etiopatogenezę zespołu endometritis-pyometra. Medycyna Wet. 1998, 54, 239-242.
• 4.Blendinger K.: Untersuchungen zum hormonellen Status von Hündinnen mit Pyometra und Effekte einer Antigestagenanwendung auf den Krankheitsverlauf und die Uterusmorphologie. Praca dokt., Justus-Liebig-Universität Gießen 1995.
• 5.Blendinger K., Bostedt H., Hoffmann B.: Hormonal state and effects of the use of an antiprogestin in bitches with pyometra. J. Reprod. Fert. 1997, 51, 317-325.
• 6.Breitkopf M., Hoffmann B., Bostedt H.: Treatment of pyometra (cystis endometrial hyperplasia) in bitches with an antiprogestin. J. Reprod. Fert. 1997, Suppl. 51, 327-331.
• 7.England G. C.: Rozród i położnictwo psów według Allena. Wyd. SIMA WLW, Warszawa 1998.
• 8.Faldyna M., Laznicka A., Toman M.: Immunosuppression in bitches with pyometra. J.Small Anim. Pract. 2001, 42, 5-10.
• 9.Fernandes P. A., Bowen R. A., Sawyer H. R., Nett T. M., Gorell T. A.: Concentration of receptors for estradiol and progesterone in canine endometrium during estrus and metestrus. Am. J. Vet. 1989, 50, 64-67.
• 10.Fieni F., Bruyas J. F., Battut I., Tainturier D.: Clinical use of anti-progestins in the bitch. recent advances in small animal reproduction. International Veterinary Informatoin Service, Ithaca, New York, USA 2001.
• 11.Fieni F., Bruyas J. F., Tainturier D., Battut I.: Clinical use of antiprogestins in the treatment of metritis/pyometra in the bitch. World Veterinary Congress, Lyon 1999, 34-37.
• 12.Gajewski Z., Boryczko Z., Bostedt H., Katkiewicz M., Jurka P., Jaworek A.: Etiopatogeneza, diagnostyka i wybrane metody leczenia Endometritis-Pyometra-Complex u suk. Nowa Weterynaria 1996, 58-71.
• 13.Galac S., Kooistra H. S., Dieleman S. J., Cestnik V., Okkens C.: Effects of aglepristone, a progesterone receptor antagonist, administrated during the early luteal phase in non-pregnant bitches. Theriogenology 2004, 62, 494-500.
• 14.Hoffmann B., Lemmer W., Bostedt H., Failing K.: Die Anwendung des Antigestagenes Aglepristone zur konservativen Behandlung der Pyometra bei der Hündin. Tierärztl. Praxis 2000 (K), 28, 323-329.
• 15.Hoffmann B., Riesenbeck A., Klein R.: Reproductive endocrinology of bitches. Anim. Reprod. Sci. 1996, 42, 275-288.
• 16.Hoffmann B., Schuler G.: Receptor blockers - general aspects with respect to their use in domestic animal reproduction. Anim. Reprod. Sci. 2000, 60-61, 295-312.
• 17.Ingarden J., Ingarden M.: Endometritis-pyometra complex u suk - wciąż trudny temat dla lekarza weterynarii. Mag. Wet. 2003, 12, 19-24.
• 18.Lemmer W.: Untersuchungen zur konservativen Pyometrabehandlung der Hündin mittels eines Antigestagens im Rahmen einer offenen klinischen Studie. Praca dokt., Justus-Liebig-Universität Gießen 1999.
• 19.Mercier P.: Alizin Technical Profile. Virbac, Medical Department 2002.
• 20.Trasch K., Wehrend A., Bostedt H.: Follow-up examinations of bitches after conservative treatment of pyometra with the antigestagen aglepristone. J. Vet. Med. A 2003, 50, 375-379.
• 21.Zduńczyk S., Janowski T.: Zaburzenia rozrodu psów i kotów. Wyd. UWM, Olsztyn 2003.