Serum immunoglobulin IgG subclass distribution of antibody responses to Yop proteins and lipopolysaccharide of Yersinia enterocolitica in patients with yersiniosis

• Autorzy: Rastawicki W , Jakubczak A.
• Języki publikacji: EN

Abstrakty

EN

To assess the humoral immunological responses at the IgG subclass level in yersiniosis specific antibody responses against lipopolysac-charide of Yersinia enterocolitica O3 (LPS) and Yersinia Yop proteins were analyzed by ELISA. Thirty five patients with arthritis and forty nine patients with uncomplicated yersiniosis were included in the study. Analysis of the IgG subclass responses to the LPS revealed that the subclass distribution for both groups of patients was IgG2>IgG1>IgG3. The concentration of IgG4 was below detection level. The predominant antibody responses to Yop proteins were IgG1 >IgG3>IgG2>IgG4 but the frequency of detection of particular IgG subclass antibodies were dependent on the age of patients. Generally, the frequency of occurrence of IgG2 antibodies for Yop proteins of Yersinia together increased with age reaching its peak among individuals aged above 40 years. On the other hand, IgG1 for Yop proteins and IgG3 for Y. enterocolitica LPS were diagnosed more often in serum samples obtained from children than from adults. We also found significantly higher frequency of IgG4 to Yop proteins of Y. enterocolitica in men than in women.

Słowa kluczowe

EN

human disease; patient; lipopolysaccharide; Yop protein; ELISA test; serum immunoglobulin; Yersinia enterocolitica; yersiniosis; distribution; antibody response

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2007
• Tom: 56
• Numer: 4
• Opis fizyczny: p.233-238,fig.,ref.

Twórcy

autor

Rastawicki W

• National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland

autor

Jakubczak A.

Bibliografia

• Chandler N.D. and M.T. Parisi 1994. Yersinia enterocolitica masquerading as appendicitis. Arch. Pediatr. Adol. Med. 148: 527-528.
• Chethamarakshan V., M.V. Kumutha, J. Vadivelu, and S.D. Puthucheary. 2001. Distribution of immunoglobulin classes and IgG subclasses against a culture filtrate antigen of Burkholderia pseudomallei in melioidosis patients. J. Med. Microbiol. 50: 55-61.
• Berkel A.I., I. Tezcan, F. Ersoy and O. Sanal. 1994. Serum immunoglobulin G subclass values in healthy Turkish children and adults. Turk. J. Pediatr. 36: 197-204.
• Gaston J.S.H., C. Cox and K. Granfors. 1999. Clinical and experimental evidence for persistent Yersinia infection in reactive arthritis. Arth. Rheum. 31: 386-390.
• Granfors K., M.K. Viljanen, and A. Toivanen. 1981. Measurement of immunoglobulin M, immunoglobulin G and immunoglobulin A antibodies against Yersinia enterocolitica by enzyme-linked immunosorbent assay: comparison of lipopolysaccharide and whole bacterium as antigen. J. Clin. Microbiol. 14: 6-14.
• Gregorek H. D. Imielska, J. Gornicki, J. Mikołajewicz and K. Madaliński. 1994. Development of IgG subclasses in healthy polish children. Arch. Immunol. Ther. Exp. 42: 377-382.
• Haarbrink M., A.J. Terhell, K. Abadi, M. Asri, F. de Medeiros and M. Yazdanbakhsh. 1999. Anti-filarial IgG4 in men and women living in Brugia malayi - endemic areas. Trop. Med. int. Health 4: 93-97.
• Hamilton R.G. 1987. Human IgG subclass measurements in the clinical laboratory. Clin. Chem. 33: 1707-1725.
• Heesemann J, U. Gross, N. Schmidt and R. Laufs. 1986. Immunochemical analysis of plasmid-encoded proteins released by enteropathogenic Yersinia sp. grown in calcium-deficient media. Infect. Immun. 54: 561-567.
• Holst O. 2003. Lipopolysaccharides of Yersinia. An overview. Adv. Exp. Med. Biol. 529: 219-228.
• Islam D., B. Wretlind, M. Ryd, A.A. Lindberg and B. Christensson. 1995. Immunoglobulin subclass distribution and dynamics of Shiigella-specific antibody responses in serum and stool samples in shigellosis. Infect. Immun. 63: 2054-2061.
• Lundkvist Ä., S. Björsten and B. Niklasson. 1993. Immunoglobulin G subclass responses against the structural components of Puumala virus. J. Clin. Microbiol. 31: 368-372.
• Mäki-Ikola O., J. Heesemann, A. Toivanen and K. Granfors. 1997. High frequency of Yersinia antibodies in healthy populations in Finland and Germany. Rheumatol. Int. 16: 227-229.
• Mattila P.S., V. Valtonen, M.R. Tuori and O. Makela. 1985. Antibody response in arthritic and uncomplicated Yersinia enterocolitica infections. J. Clin. Immunol. 5: 404-411.
• Satoh M., H. Torna, S. Kiyuna, Y. Shiroma, A. Kokaze and Y. Sato. 2004. Association of a sex-related difference of Strongyloides stercorals - specific IgG4 antibody titer with the efficacy of treatment of strongyloidiasis. Am. J. Trop. Med. Hyg. 71: 107-111.
• Shackelford P.G., D.M. Granoff, S.J. Nelson, M.G. Scott, D.S. Smith and M.H. Nahm. 1987. Subclass distribution of human antibodies to Haemophilus influenzae type b capsular polysaccharide. J. Immunol. 138: 587-592.
• Schenk K. and T.E. Michaelsen. 1987. IgG subclass distribution of serum antibodies against lipopolysaccharide from Bacteroides gingivalis in periodontal health and disease. Acta Pathol. Microbiol. Scand. 95: 41-46.
• Sieber G.R., P.H. Schur, A.L. Aisenbcrg, S.A. Weitzmann and G. Schiffman. 1980. Correlation between serum IgG-2 concentrations and the antibody response to bacterial polysaccharide antigens. New Engl. J. Med. 303: 178-182.
• Spiegelberg H.L. 1974. Biological activities of immunoglobulins of different classes and subclasses. Adv. Immunol. 19: 259-294.
• Straley S.C., E. Skrzypek, G.V. Plano and J.B. Bliska. 1993. Yops of Yersinia spp. pathogenic for humans. Infect. Immun. 61: 3103-3110.
• Suzuki T., A.E. Gorzynski and E. Neter. 1964. Separation by ethanol of common and somatic antigens of Enterobacteriaceae. J. Bacteriol. 88: 1240-1243.
• Toptygina A.P., A.L. Pukhalsky and V.A. Alioshkin. 2005. Immunoglobulin G subclass profile of antimeasles response in vaccinated children and in adults with measles history. Clin. Diag. Lab. Immunol. 12: 845-847.
• Touraud J.P., Y. Dutronc, P. Tsan, E. Collet and D. Lambert. 2000. Cutaneous manifestations of Yersinia enterocolitica infection. Ann. Dermatol. Venereal. 127: 741-744.
• Vantrappen G., H.O. Agg, E. Ponette, K. Gebers and P. Bertrand. 1979. Yersinia enteritis and enterocolitis: gastroenterological aspects. Gastroenterology 72: 220-227.
• Whitney C, J. Ant, B. Moncla, B. Johnson, R.C. Page and D. Engel. 1992. Serum immunoglobulin G antibody to Porphyro-monas gingivalis in rapidly progressive periodontitis: titer, avidity, and subclass distribution. Infect. Immun. 60: 2194-2200.
• Widhe M., C. Ekerfelt, P. Forsberg, S. Bergström and J. Ernerudh. 1998. IgG subclasses in Lyme borreliosis: A study of specific IgG subclass distribution in an interferon-γ -predomi-nated disease. Scand. J. Immunol. 47: 575-581.
• Wilson M.E. and R.G. Hamilton. 1992. Immunoglobulin G subclass response of localized juvenile periodontitis patients to Actinobacillus actinomycetemcomitans Y4 lipopolysaccharide. Infect. Immun. 60: 1806-1812.